Results 111 to 120 of about 107,605 (342)

Reproducibility of lymphovascular space invasion (LVSI) assessment in endometrial cancer [PDF]

, 2019
Aims Lymphovascular space invasion (LVSI) in endometrial cancer (EC) is an important prognostic variable impacting on a patient's individual recurrence risk and adjuvant treatment recommendations.
Bartosch, Carla, Bosse, Tjalling, Genestie, Catherine, Lax, Sigurd F, McCluggage, W Glenn, Nout, Remi, Oosting, Jan, Peters, Elke E M, Singh, Naveena, Smit, Huub C S H, Smit, Vincent T H B M, Van de Vijver, Koen   +11 more
core   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

High-risk corneal allografts : A therapeutic challenge [PDF]

, 2016
Peer reviewedPublisher ...
Forrester, John V, Griffith, May, Kuffová, Lucia, Rajendran, Vijayalakshmi, Yu, Tian   +4 more
core   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway [PDF]

, 2014
Background: Signaling through vascular endothelial growth factor C (VEGF–C) and VEGF receptor 3 (VEGFR-3) plays a central role in lymphangiogenesis and the metastasis of several cancers via the lymphatics.
Groopman, Jerome E, Jiang, Shuxian, Kuzontkoski, Paula M, Li, Dean Y, Yu, Jinlong, Zhang, Xuefeng, Zhu, Weiquan   +6 more
core   +2 more sources

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source

Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]

, 2013
Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Plate, Karl H., Schneider, Fabian T., Wittko-Schneider, Ina M.   +2 more
core   +1 more source

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, EarlyView.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

Slit2/Robo4 signaling modulates HIV-1 gp120-induced lymphatic hyperpermeability.

PLoS Pathogens, 2012
Dissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium. HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is largely unexplored.
Xuefeng Zhang, Jinlong Yu, Paula M Kuzontkoski, Weiquan Zhu, Dean Y Li, Jerome E Groopman   +5 more
doaj   +1 more source

Apolipoprotein A‐I Modulates Atherosclerosis Through Lymphatic Vessel‐Dependent Mechanisms in Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundSubcutaneously injected lipid‐free apoA‐I (apolipoprotein A‐I) reduces accumulation of lipid and immune cells within the aortic root of hypercholesterolemic mice without increasing high‐density lipoprotein–cholesterol concentrations.
Andreea Milasan, Gabriel Jean, François Dallaire, Jean‐Claude Tardif, Yahye Merhi, Mary Sorci‐Thomas, Catherine Martel   +6 more
doaj   +1 more source