Results 1 to 10 of about 109,302 (309)
Digging deeper into lymphatic vessel formation
BMC Cell Biology, 2011 Background Abnormal lymphatic vessel formation (lymphangiogenesis) is associated with different pathologies such as cancer, lymphedema, psoriasis and graft rejection.
Thiry Marc +9 more
doaj +3 more sources
Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development [PDF]
eLife, 2017 The lymphatic system controls fluid homeostasis and the clearance of macromolecules from interstitial compartments. In mammals brain lymphatics were only recently discovered, with significant implications for physiology and disease. We examined zebrafish
Max van Lessen +5 more
doaj +3 more sources
Macroautophagy in lymphatic endothelial cells inhibits T cell–mediated autoimmunity
Journal of Experimental Medicine, 2021 Lymphatic endothelial cells (LECs) present peripheral tissue antigens to induce T cell tolerance. In addition, LECs are the main source of sphingosine-1-phosphate (S1P), promoting naive T cell survival and effector T cell exit from lymph nodes (LNs). Autophagy is a physiological process essential for cellular homeostasis.
Guillaume harlé +2 more
exaly +6 more sources
How Lymphatic Endothelial Cells Destabilize Regulatory T Cells. [PDF]
Arterioscler Thromb Vasc Biol, 2023 Lyu Q, Ley K.
europepmc +3 more sources
Cells with Many Talents: Lymphatic Endothelial Cells in the Brain Meninges
Cells, 2021 The lymphatic system serves key functions in maintaining fluid homeostasis, the uptake of dietary fats in the small intestine, and the trafficking of immune cells. Almost all vascularized peripheral tissues and organs contain lymphatic vessels. The brain
Irina Suárez, Stefan Schulte-Merker
doaj +1 more source
TGF-β signaling in lymphatic vascular vessel formation and maintenance
Frontiers in Physiology, 2022 Transforming growth factor (TGF)-β and its family members, including bone morphogenetic proteins (BMPs), nodal proteins, and activins, are implicated in the development and maintenance of various organs. Here, we review its role in the lymphatic vascular
Fumiko Itoh, Tetsuro Watabe
doaj +1 more source
Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment. [PDF]
PLoS ONE, 2014 Peripheral self-tolerance eliminates lymphocytes specific for tissue-specific antigens not encountered in the thymus. Recently, we demonstrated that lymphatic endothelial cells in mice directly express peripheral tissue antigens, including tyrosinase ...
Jarish N Cohen +8 more
doaj +1 more source
Fine filaments in lymphatic endothelial cells [PDF]
The Journal of Cell Biology, 1976 Several and various types of cells contain fine cytoplasmic filaments closely resembling the myofilaments of muscle cells (2, 18, 23, 24). In many of these cells and especially when cultured, it has been demonstrated that some of these filaments react with heavy meromyosin (HMM) in the same way as do the actin filaments of muscle cells (3, 6 7).
J M, Lauweryns, J, Baert, W, De Loecker
openaire +2 more sources
Cells, 2023 At present, only a few reports have addressed the possible contribution of the lymphatic vascular system to the pathogenesis of systemic sclerosis (SSc).
Irene Rosa +6 more
doaj +1 more source
Molecular characterization of lymphatic endothelial cells [PDF]
Proceedings of the National Academy of Sciences, 2002 The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial fluid and proteins and is an important entry point for leukocytes and tumor cells. Specialized functions of lymphatics suggest differences in the molecular composition of the lymphatic and blood vascular endothelium.
Simona Podgrabinska +6 more
openaire +2 more sources