Antigen-presenting cells and antigen presentation in tertiary lymphoid organs [PDF]
, 2016 Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Bedaj, Marija +3 more
core +1 more source
Microarray analyses demonstrate the involvement of type i interferons in psoriasiform pathology development in D6-deficient mice [PDF]
, 2013 The inflammatory response is normally limited by mechanisms regulating its resolution. In the absence of resolution, inflammatory pathologies can emerge, resulting in substantial morbidity and mortality.
Baldwin, H.M. +9 more
core +1 more source
A robust in vitro model for trans-lymphatic endothelial migration
Scientific Reports, 2017 Trans-endothelial migration (TEM) is essential for leukocyte circulation. While much is known about trans-blood endothelial migration, far less is known about trans-lymphatic endothelial migration.
Yanbao Xiong +7 more
doaj +1 more source
Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro [PDF]
, 2017 Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microenvironment are linked to the presence of LVI and angiogenesis.
Ahmad, Narmeen +5 more
core +2 more sources
Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4. [PDF]
PLoS ONE, 2017 Myeloid-derived lymphatic endothelial cells (M-LECP) are induced by inflammation and play an important role in adult lymphangiogenesis. However, the mechanisms driving M-LECP differentiation are currently unclear.
Lisa D Volk-Draper +3 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2017 Background: Recent evidence has indicated that long non-coding RNA (lncRNA) is involved in the pathogenesis of type 2 diabetes, but nothing is known about lncRNA expression changes of lymphatic endothelial cells in response to type 2 diabetes.
Min Qi +9 more
doaj +1 more source
A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo [PDF]
, 2012 In vivo imaging has revolutionized understanding of the spatiotemporal complexity that subserves the generation of successful effector and regulatory immune responses.
Andrea J. White +40 more
core +2 more sources
Lymphatic Endothelial Cell Progenitors in the Tumor Microenvironment [PDF]
, 2020 Tumor lymphatics play a key role in cancer progression as they are solely responsible for transporting malignant cells to regional lymph nodes (LNs), a process that precedes and promotes systemic lethal spread. It is broadly accepted that tumor lymphatic sprouting is induced mainly by soluble factors derived from tumor-associated macrophages (TAMs) and
Sophia, Ran, Lisa, Volk-Draper
openaire +2 more sources
Cell Reports, 2017 Summary: Trafficking cells frequently transmigrate through epithelial and endothelial monolayers. How monolayers cooperate with the penetrating cells to support their transit is poorly understood.
Kari Vaahtomeri +7 more
doaj +1 more source
Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos. [PDF]
, 2018 Arteries and veins are formed independently by different types of endothelial cells (ECs). In vascular remodeling, arteries and veins become connected and some arteries become veins. It is unclear how ECs in transforming vessels change their type and how
Ablooglu, Ararat J +6 more
core +3 more sources