Results 1 to 10 of about 24,495 (118)

PROX1 loss in adult mouse Schlemm’s canal causes permanent ocular hypertension [PDF]

JCI Insight
Glaucoma is associated with ocular hypertension, and lowering intraocular pressure is the primary objective of current therapies. Recent studies have established a key role for Schlemm’s canal endothelium in this pressure increase and have shown that it ...
Sofia Lara Ochoa, Hoi-Lam Li, Hyeohn Kim, Zihang Yan, Natalia C. Mendonca, Pan Liu, Hyunjoo J. Lee, Michael P. Vincent, Sultan Almunif, Hao F. Zhang, Haiyan Gong, Evan A. Scott, Mark Johnson, Benjamin R. Thomson   +13 more
doaj   +2 more sources

Meningeal lymphatic-associated brain swelling in acute stroke. [PDF]

PLoS ONE
Brain meninges contain lymphatic vessels that play roles in clearance of extracellular solute in the central nervous system. But, whether and how the system is involved in acute stroke remains to be fully explored.
Rohan Mahesh Patil, Dong Bin Back, Gen Hamanaka, Rakhi Desai, Ayumi Hayakawa, Su Jing Chan, Bum Ju Ahn, Giuseppe Pignataro, Kazuhide Hayakawa, Elga Esposito   +9 more
doaj   +2 more sources

Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology

Frontiers in Physiology, 2021
The lymphatic system is a vascular system comprising modified lymphatic endothelial cells, lymph nodes and other lymphoid organs. The system has diverse, but critical functions in both physiology and pathology, and forms an interface between the blood ...
Zarah B. Tabrizi, Nada S. Ahmed, Joseph L. Horder, Sarah J. Storr, Andrew V. Benest   +4 more
doaj   +1 more source

Lymphatic Clearance of Immune Cells in Cardiovascular Disease

Cells, 2021
Recent advances in our understanding of the lymphatic system, its function, development, and role in pathophysiology have changed our views on its importance. Historically thought to be solely involved in the transport of tissue fluid, lipids, and immune
Christophe Ravaud, Nikita Ved, David G. Jackson, Joaquim Miguel Vieira, Paul R. Riley   +4 more
doaj   +1 more source

KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi's sarcoma studies.

PLoS Pathogens, 2023
Kaposi's sarcoma herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS), a hyperplasia consisting of enlarged malformed vasculature and spindle-shaped cells, the main proliferative component of KS.
Krista Tuohinto, Terri A DiMaio, Elina A Kiss, Pirjo Laakkonen, Pipsa Saharinen, Tara Karnezis, Michael Lagunoff, Päivi M Ojala   +7 more
doaj   +1 more source

Is It All about Endothelial Dysfunction? Focusing on the Alteration in Endothelial Integrity as a Key Determinant of Different Pathological Mechanisms

Biomedicines, 2022
The endothelium is composed of a monolayer of endothelial cells (ECs) covering the inner side of arterial, venous and lymphatic vessels [...]
Pasquale Ambrosino, Silvestro Ennio D’Anna, Guido Grassi, Mauro Maniscalco   +3 more
doaj   +1 more source

Hematopoietic stem cells contribute to lymphatic endothelium.

PLoS ONE, 2008
BackgroundAlthough the lymphatic system arises as an extension of venous vessels in the embryo, little is known about the role of circulating progenitors in the maintenance or development of lymphatic endothelium.
Shuguang Jiang, Alexis S Bailey, Devorah C Goldman, John R Swain, Melissa H Wong, Philip R Streeter, William H Fleming   +6 more
doaj   +1 more source

Plasticity of blood- and lymphatic endothelial cells and marker identification. [PDF]

PLoS ONE, 2013
The distinction between lymphatic and blood vessels is biologically fundamental. Here we wanted to rigorously analyze the universal applicability of vascular markers and characteristics of the two widely used vascular model systems human microvascular ...
Johannes Keuschnigg, Sirkku Karinen, Kaisa Auvinen, Heikki Irjala, John-Patrick Mpindi, Olli Kallioniemi, Sampsa Hautaniemi, Sirpa Jalkanen, Marko Salmi   +8 more
doaj   +1 more source

Coagulation in Lymphatic System

Frontiers in Cardiovascular Medicine, 2021
The lymphatic system maintains homeostasis of the internal environment between the cells in tissues and the blood circulation. The coagulation state of lymph is determined by conditions of coagulation factors and lymphatic vessels. Internal obliteration,
Wendi Zhang, Wendi Zhang, Wendi Zhang, Jiang Li, Jiangjiu Liang, Xiumei Qi, Jinghui Tian, Ju Liu, Ju Liu   +8 more
doaj   +1 more source

Locally Triggered Release of the Chemokine CCL21 Promotes Dendritic Cell Transmigration across Lymphatic Endothelia

Cell Reports, 2017
Summary: Trafficking cells frequently transmigrate through epithelial and endothelial monolayers. How monolayers cooperate with the penetrating cells to support their transit is poorly understood.
Kari Vaahtomeri, Markus Brown, Robert Hauschild, Ingrid De Vries, Alexander Franz Leithner, Matthias Mehling, Walter Anton Kaufmann, Michael Sixt   +7 more
doaj   +1 more source