Results 21 to 30 of about 5,011,546 (295)

Targeting Receptor Tyrosine Kinase on Lymphatic Endothelial Cells for the Therapy of Colon Cancer Lymph Node Metastasis

Neoplasia: An International Journal for Oncology Research, 2006
Oral treatment with the dual-receptor tyrosine kinase inhibitor AEE788 effectively reduces the number of peritumoral lymphatic vessels and the incidence of lymph node metastasis in nude mice with human HT29 colon cancer cells growing in the cecum ...
Robert B. Rebhun, Robert R. Langley, Kenji Yokoi, Dominic Fan, Jeffrey E. Gershenwald, Isaiah J. Fidler   +5 more
doaj   +1 more source

Regulation of T-cell Tolerance by Lymphatic Endothelial Cells [PDF]

Journal of Clinical & Cellular Immunology, 2014
Lymphatic endothelial cells are most often thought of as structural cells that form the lymphatic vasculature, which transports fluid out of peripheral tissues and transports antigens and antigen presenting cells to lymph nodes. Recently, it has been shown that lymphatic endothelial cells also dynamically respond to and influence the immune response in
Rouhani, Sherin J., Eccles, Jacob D., Tewalt, Eric F., Engelhard, Victor H.   +3 more
openaire   +2 more sources

Tumor-induced myeloid cell plasticity toward lymphatic endothelium [PDF]

, 2009
Tumor-associated lymphangiogenesis contributes to tumor progression by regulating interstitial fluid pressure, transporting immune cells to the tumor site and providing a route for metastatic dissemination.
Baeriswyl, Vanessa
core   +1 more source

Lymphatic Endothelial Differentiation in Pulmonary Lymphangioleiomyomatosis Cells [PDF]

Journal of Histochemistry & Cytochemistry, 2013
Pulmonary lymphangioleiomyomatosis (LAM) is a rare, low-grade neoplasm affecting almost exclusively women of childbearing age. LAM belongs to the family of perivascular epithelioid cell tumors, characterized by spindle and epithelioid cells with smooth muscle and melanocytic differentiation. LAM cells infiltrate the lungs, producing multiple, bilateral
Jennifer M, Davis, Elizabeth, Hyjek, Aliya N, Husain, Le, Shen, Jennifer, Jones, Lucia A, Schuger   +5 more
openaire   +2 more sources

A Role for All-Trans-Retinoic Acid in the Early Steps of Lymphatic Vasculature Development [PDF]

, 2010
The molecular mechanisms that regulate the earliest steps of lymphatic vascular system development are unknown. To identify regulators of lymphatic competence and commitment, we used an in vitro vascular assay with mouse embryonic stem cell-derived ...
Dabouras, Vasilios, Marino, Daniela, Vasilios Dabouras, Detmar, Michael, Braendli, Andre W., Michael Detmar, André W. Brändli, Daniela Marino, Brändli AW, Marino D, Dabouras V, Detmar M   +11 more
core   +1 more source

Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration

Cell Reports, 2020
Summary: Regulatory T cells (Tregs) express high levels of cell surface lymphotoxin alpha beta (LTα1β2) to activate the LT beta receptor (LTβR) on the lymphatic endothelial cells (LECs), modulating LEC adhesion molecules, intercellular junctions, and ...
Wenji Piao, Yanbao Xiong, Lushen Li, Vikas Saxena, Kile D. Smith, Keli L. Hippen, Christina Paluskievicz, Marina Willsonshirkey, Bruce R. Blazar, Reza Abdi, Jonathan S. Bromberg   +10 more
doaj   +1 more source

Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation

Frontiers in Cell and Developmental Biology, 2021
Microenvironmental signals produced during development or inflammation stimulate lymphatic endothelial cells to undergo lymphangiogenesis, in which they sprout, proliferate, and migrate to expand the vascular network.
Delayna Paulson, Delayna Paulson, Rebecca Harms, Rebecca Harms, Cody Ward, Cody Ward, Mackenzie Latterell, Mackenzie Latterell, Gregory J. Pazour, Darci M. Fink, Darci M. Fink   +10 more
doaj   +1 more source

Lymphatic vascular morphogenesis in development, physiology, and disease [PDF]

, 2011
The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the
Amélie Sabine, Petrova, T.V., Stefan Schulte-Merker, Sabine, A., Schulte-Merker, S., Petrova, T. V., Tatiana V. Petrova, Schulte-Merker, Stefan, Sabine, Amélie, Petrova, Tatiana V.   +9 more
core   +2 more sources

Isolation of LYVE-1+ Endothelial Cells from Mouse Embryos

Bio-Protocol, 2018
Lymphatic vessel endothelial hyaluronan receptor 1, or LYVE-1, is a type 1 integral membrane glycoprotein expressed by lymphatic endothelial cells (LECs). LYVE-1 is commonly used as a biological marker to visually distinguish developing lymphatic vessels
Patrick Crosswhite
doaj   +1 more source

Metabolic Analysis of Lymphatic Endothelial Cells [PDF]

, 2018
Metabolism is pivotal for formation of the lymphatic vasculature. Understanding metabolism in lymphatic endothelial cells (LECs) requires quantitative characterization of specific metabolic pathways. Here we describe methods for using radioactive tracers to assess flux rates of glycolysis, fatty acid β-oxidation, glucose oxidation, and glutamine ...
Pengchun, Yu, Tiago C, Alves, Richard G, Kibbey, Michael, Simons   +3 more
openaire   +2 more sources