Results 21 to 30 of about 109,302 (309)

Metabolic Analysis of Lymphatic Endothelial Cells [PDF]

, 2018
Metabolism is pivotal for formation of the lymphatic vasculature. Understanding metabolism in lymphatic endothelial cells (LECs) requires quantitative characterization of specific metabolic pathways. Here we describe methods for using radioactive tracers to assess flux rates of glycolysis, fatty acid β-oxidation, glucose oxidation, and glutamine ...
Pengchun, Yu, Tiago C, Alves, Richard G, Kibbey, Michael, Simons   +3 more
openaire   +2 more sources

Isolation of LYVE-1+ Endothelial Cells from Mouse Embryos

Bio-Protocol, 2018
Lymphatic vessel endothelial hyaluronan receptor 1, or LYVE-1, is a type 1 integral membrane glycoprotein expressed by lymphatic endothelial cells (LECs). LYVE-1 is commonly used as a biological marker to visually distinguish developing lymphatic vessels
Patrick Crosswhite
doaj   +1 more source

Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation

Frontiers in Cell and Developmental Biology, 2021
Microenvironmental signals produced during development or inflammation stimulate lymphatic endothelial cells to undergo lymphangiogenesis, in which they sprout, proliferate, and migrate to expand the vascular network.
Delayna Paulson, Delayna Paulson, Rebecca Harms, Rebecca Harms, Cody Ward, Cody Ward, Mackenzie Latterell, Mackenzie Latterell, Gregory J. Pazour, Darci M. Fink, Darci M. Fink   +10 more
doaj   +1 more source

Lymphatic Endothelial Differentiation in Pulmonary Lymphangioleiomyomatosis Cells [PDF]

Journal of Histochemistry & Cytochemistry, 2013
Pulmonary lymphangioleiomyomatosis (LAM) is a rare, low-grade neoplasm affecting almost exclusively women of childbearing age. LAM belongs to the family of perivascular epithelioid cell tumors, characterized by spindle and epithelioid cells with smooth muscle and melanocytic differentiation.
Jennifer M, Davis, Elizabeth, Hyjek, Aliya N, Husain, Le, Shen, Jennifer, Jones, Lucia A, Schuger   +5 more
openaire   +2 more sources

An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo. [PDF]

PLoS ONE, 2013
Afadin is an intracellular binding partner of nectins, cell-cell adhesion molecules, and plays important roles in the formation of cell-cell junctions. Afadin-knockout mice show early embryonic lethality, therefore little is known about the function of ...
Takashi Majima, Keisuke Takeuchi, Keigo Sano, Masanori Hirashima, Dimitar P Zankov, Miki Tanaka-Okamoto, Hiroyoshi Ishizaki, Jun Miyoshi, Hisakazu Ogita   +8 more
doaj   +1 more source

Intestinal Lymphatic Endothelial Cells Produce R-Spondin3 [PDF]

Scientific Reports, 2018
AbstractThe R-Spondin (R-Spo) family regulates WNT signaling and stimulates the proliferation and differentiation of intestinal stem cells (ISCs). R-Spo plays a critical role in maintaining intestinal homeostasis, but endogenous producers of R-Spo in the intestine remain to be investigated.
Reiki Ogasawara, Daigo Hashimoto, Shunsuke Kimura, Eiko Hayase, Takahide Ara, Shuichiro Takahashi, Hiroyuki Ohigashi, Kosuke Yoshioka, Takahiro Tateno, Emi Yokoyama, Ko Ebata, Takeshi Kondo, Junichi Sugita, Masahiro Onozawa, Toshihiko Iwanaga, Takanori Teshima   +15 more
openaire   +3 more sources

Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation

Stem Cell Reports, 2019
Summary: Exogenous cues involved in the regulation of the initial steps of lymphatic endothelial development remain largely unknown. We have used an in vitro model based on the co-culture of vascular precursors derived from mouse embryonic stem cell (ESC)
Mariela Subileau, Galina Merdzhanova, Delphine Ciais, Véronique Collin-Faure, Jean-Jacques Feige, Sabine Bailly, Daniel Vittet   +6 more
doaj   +1 more source

Endothelial cell plasticity: how to become and remain a lymphatic endothelial cell [PDF]

Development, 2010
Lineage commitment and differentiation into mature cell types are mostly considered to be unidirectional and irreversible processes. However, recent results have challenged this by showing that terminally differentiated cell types can be reprogrammed into other cell types, an important step towards devising strategies for gene therapy and tissue ...
Guillermo, Oliver, R Sathish, Srinivasan
openaire   +2 more sources

Constitutive Expression of the α4 Integrin Correlates with Tumorigenicity and Lymph Node Metastasis of the B16 Murine Melanoma

Neoplasia: An International Journal for Oncology Research, 2010
The lymphatic system plays a critical role in melanoma metastasis, and yet, virtually no information exists regarding the cellular and molecular mechanisms that take place between melanoma cells and the lymphatic vasculature.
Robert B. Rebhun, Hua Cheng, Jeffrey E. Gershenwald, Dominic Fan, Isaiah J. Fidler, Robert R. Langley   +5 more
doaj   +1 more source

Regulation of T-cell Tolerance by Lymphatic Endothelial Cells [PDF]

Journal of Clinical & Cellular Immunology, 2014
Lymphatic endothelial cells are most often thought of as structural cells that form the lymphatic vasculature, which transports fluid out of peripheral tissues and transports antigens and antigen presenting cells to lymph nodes. Recently, it has been shown that lymphatic endothelial cells also dynamically respond to and influence the immune response in
Rouhani, Sherin J., Eccles, Jacob D., Tewalt, Eric F., Engelhard, Victor H.   +3 more
openaire   +2 more sources