Mural Lymphatic Endothelial Cells at CNS Borders: Endothelial Heterogeneity, Functional Specialization, and Cross-Species Perspectives [PDF]
BiologyRecent advances in developmental biology and single-cell transcriptomics have revealed remarkable endothelial heterogeneity within the central nervous system, leading to the identification of specialized endothelial populations at brain border regions ...
Junxiang Xu +4 more
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Lymphatic Endothelial Cells in Health and Disease [PDF]
MedCommABSTRACT Lymphatic endothelial cells (LECs) line the lymphatic vasculature and support interstitial fluid drainage, lipid transport, and immune‐cell trafficking. Beyond these classical functions, recent studies now recognize LECs as heterogeneous, spatially organized endothelial regulators that maintain lymphatic identity while ...
Du Tang +5 more
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Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. [PDF]
PLoS Pathogens, 2010 Kaposi's sarcoma (KS) is the most common cancer among HIV-positive patients. Histogenetic origin of KS has long been elusive due to a mixed expression of both blood and lymphatic endothelial markers in KS tumor cells.
Jaehyuk Yoo +11 more
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Lymphatic Endothelial Cells and Organ-Associated Lymphangiogenesis in Tumor Microenvironment. [PDF]
CellsLymphatic vessels are a kind of heterogeneous and versatile component of the lymphatic system, with a unique ability to respond to environmental changes in different organs.
Ji RC.
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A robust in vitro model for trans-lymphatic endothelial migration
Scientific Reports, 2017 Trans-endothelial migration (TEM) is essential for leukocyte circulation. While much is known about trans-blood endothelial migration, far less is known about trans-lymphatic endothelial migration.
Yanbao Xiong +7 more
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The Scaffold Protein Liprin β-1 (PPFIBP1) and the Intermediate Filament Synemin: Potential New Markers of Lymphatic Endothelial Cells. [PDF]
CellsThere are a few molecules that are regularly used as markers for lymphatic endothelial cells (LECs) such as the adhesion molecule CD31/PEACAM1, the transcription factor PROX1, the Vascular Endothelial Growth Factor Receptor-3 (VEGFR3/FLT4), the ...
Becker J, Wilting J.
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Regulation of VEGFR3 signaling in lymphatic endothelial cells [PDF]
Frontiers in Cell and Developmental BiologyThe receptor tyrosine kinase vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3) is the principal transmembrane receptor responsible for sensing and coordinating cellular responses to environmental lymphangiogenic stimuli in lymphatic endothelial cells (LECs).
Kevin G. Kuonqui +8 more
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Characterization of endothelial cells of lymphatic vessels [PDF]
, 2001 Endothelial cells form the inner lining of blood and lymphatic vessels. In mice only tumours of the blood vessel endothelium (haemangiomas) have been thus far reported. In the first part of this thesis is described a highly reproducible method for the induction of benign tumours of the lymphatic endothelial cells (lymphangioma) in mice, by ...
Mancardi, Sabrina
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Cell Fate Determination of Lymphatic Endothelial Cells [PDF]
International Journal of Molecular Sciences, 2020 The lymphatic vasculature, along with the blood vasculature, is a vascular system in our body that plays important functions in fluid homeostasis, dietary fat uptake, and immune responses. Defects in the lymphatic system are associated with various diseases such as lymphedema, atherosclerosis, fibrosis, obesity, and inflammation.
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Endothelial cell plasticity: how to become and remain a lymphatic endothelial cell [PDF]
Development, 2010 Lineage commitment and differentiation into mature cell types are mostly considered to be unidirectional and irreversible processes. However, recent results have challenged this by showing that terminally differentiated cell types can be reprogrammed into other cell types, an important step towards devising strategies for gene therapy and tissue ...
Guillermo, Oliver, R Sathish, Srinivasan
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