Results 11 to 20 of about 109,302 (309)

Cell Fate Determination of Lymphatic Endothelial Cells [PDF]

International Journal of Molecular Sciences, 2020
The lymphatic vasculature, along with the blood vasculature, is a vascular system in our body that plays important functions in fluid homeostasis, dietary fat uptake, and immune responses. Defects in the lymphatic system are associated with various diseases such as lymphedema, atherosclerosis, fibrosis, obesity, and inflammation.
openaire   +2 more sources

Regulation of VEGFR3 signaling in lymphatic endothelial cells. [PDF]

Front Cell Dev Biol
The receptor tyrosine kinase vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3) is the principal transmembrane receptor responsible for sensing and coordinating cellular responses to environmental lymphangiogenic stimuli in lymphatic endothelial cells (LECs).
Kuonqui KG, Campbell AC, Pollack BL, Shin J, Sarker A, Brown S, Park HJ, Mehrara BJ, Kataru RP.   +8 more
europepmc   +4 more sources

Sostdc1 Secreted from Cutaneous Lymphatic Vessels Acts as a Paracrine Factor for Hair Follicle Growth

Current Issues in Molecular Biology, 2022
In our previous study, we found that lymphatic vessels stimulate hair follicle growth through paracrine effects on dermal papilla cells. However, the paracrine factors secreted from cutaneous lymphatic vessels that can activate dermal papilla cells are ...
Sun-Young Yoon, Michael Detmar
doaj   +1 more source

Aberrant lymphatic endothelial progenitors in lymphatic malformation development.

PLoS ONE, 2015
Lymphatic malformations (LMs) are vascular anomalies thought to arise from dysregulated lymphangiogenesis. These lesions impose a significant burden of disease on affected individuals.
June K Wu, Christopher Kitajewski, Maia Reiley, Connie H Keung, Julie Monteagudo, John P Andrews, Peter Liou, Arul Thirumoorthi, Alvin Wong, Jessica J Kandel, Carrie J Shawber   +10 more
doaj   +1 more source

The intestinal lymphatic system: Functions and metabolic implications [PDF]

, 2019
The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well as in immunosurveillance and removal of interstitial fluid.
Cifarelli, Vincenza, Eichmann, Anne
core   +2 more sources

Targeting Receptor Tyrosine Kinase on Lymphatic Endothelial Cells for the Therapy of Colon Cancer Lymph Node Metastasis

Neoplasia: An International Journal for Oncology Research, 2006
Oral treatment with the dual-receptor tyrosine kinase inhibitor AEE788 effectively reduces the number of peritumoral lymphatic vessels and the incidence of lymph node metastasis in nude mice with human HT29 colon cancer cells growing in the cecum ...
Robert B. Rebhun, Robert R. Langley, Kenji Yokoi, Dominic Fan, Jeffrey E. Gershenwald, Isaiah J. Fidler   +5 more
doaj   +1 more source

Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors [PDF]

, 2005
The study of lymphatic vessels and lymphatic tumors has been hampered with difficulty due to the overlapping morphological features between blood and lymphatic endothelial cells, as well as to the lack of specific lymphatic endothelial markers.
Adhemar Longatto Filho, Alitalo, Belecky-Adams, Boshoff, Breiteneder-Geleff, Carmeliet, Carreira, Fletcher, Folpe, Jackson, Jorge S. Reis-Filho, José M. Lopes, Kahn, Lohela, Makinen, Oliver, Oliver, Oliver, Padera, Papoutsi, Papper, Partanen, Paula Silva, Petrova, Rafii, Reis-Filho, Rodriguez-Niedenfuhr, Rui M. Reis, Sauter, Stanislav Tomarev, Tomarev, Weiss, Wigle, Wigle, Wilting, Witmer, Xu   +36 more
core   +1 more source

Heterogeneity and Plasticity of Lymphatic Endothelial Cells [PDF]

Seminars in Thrombosis and Hemostasis, 2010
Endothelial cells are found in most organs and tissues in our body. Despite their apparent morphological and functional similarities, endothelial cells exhibit remarkable heterogeneity and plasticity. In a strict sense, no two endothelial cells are identical in terms of their biological, immunological, functional, metabolic, morphological, and ...
Sunju, Lee, Inho, Choi, Young-Kwon, Hong
openaire   +2 more sources

Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration

Cell Reports, 2020
Summary: Regulatory T cells (Tregs) express high levels of cell surface lymphotoxin alpha beta (LTα1β2) to activate the LT beta receptor (LTβR) on the lymphatic endothelial cells (LECs), modulating LEC adhesion molecules, intercellular junctions, and ...
Wenji Piao, Yanbao Xiong, Lushen Li, Vikas Saxena, Kile D. Smith, Keli L. Hippen, Christina Paluskievicz, Marina Willsonshirkey, Bruce R. Blazar, Reza Abdi, Jonathan S. Bromberg   +10 more
doaj   +1 more source

Engineering Blood and Lymphatic Microvascular Networks in Fibrin Matrices [PDF]

, 2017
Vascular network engineering is essential for nutrient delivery to tissue-engineered constructs and, consequently, their survival. In addition, the functionality of tissues also depends on tissue drainage and immune cell accessibility, which are the main
Hasenberg, Tobias, Holnthoner, Wolfgang, Knezevic, Lea, Marx, Uwe, Mühleder, Severin, Priglinger, Eleni, Redl, Heinz, Schaupper, Mira, Schimek, Katharina   +8 more
core   +1 more source