Results 31 to 40 of about 5,011,546 (295)

Angiogenic potential of endothelial progenitor cells and embryonic stem cells [PDF]

, 2011
Background: Endothelial progenitor cells (EPCs) are implicated in a range of pathological conditions, suggesting a natural therapeutic role for EPCs in angiogenesis.
Kelly, RDW, Stuart Egginton, Rae, Peter, Richard DW Kelly, StJohn, JC, Peter C Rae, St. John, Justin C., Justin C St John, Rae, Peter C., Egginton, Stuart, Rae, PC, Egginton, S, Kelly, Richard D. W., St John, JC   +13 more
core   +1 more source

An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo. [PDF]

PLoS ONE, 2013
Afadin is an intracellular binding partner of nectins, cell-cell adhesion molecules, and plays important roles in the formation of cell-cell junctions. Afadin-knockout mice show early embryonic lethality, therefore little is known about the function of ...
Takashi Majima, Keisuke Takeuchi, Keigo Sano, Masanori Hirashima, Dimitar P Zankov, Miki Tanaka-Okamoto, Hiroyoshi Ishizaki, Jun Miyoshi, Hisakazu Ogita   +8 more
doaj   +1 more source

Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation

Stem Cell Reports, 2019
Summary: Exogenous cues involved in the regulation of the initial steps of lymphatic endothelial development remain largely unknown. We have used an in vitro model based on the co-culture of vascular precursors derived from mouse embryonic stem cell (ESC)
Mariela Subileau, Galina Merdzhanova, Delphine Ciais, Véronique Collin-Faure, Jean-Jacques Feige, Sabine Bailly, Daniel Vittet   +6 more
doaj   +1 more source

Reversible trans-differentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro [PDF]

, 2010
Blood vascular cells and lymphatic endothelial cells (BECs and LECs, respectively) form two separate vascular systems and are functionally distinct cell types or lineages with characteristic gene expression profiles.
Thompson, Erik W., Ernst Pöschl, Lafleur, Marc A., Handsley, M. M., Lindsay S. Cooley, Pennington, C. J., Dylan R. Edwards, Edwards, Dylan R., Edwards, D. R., Pöschl, Ernst, Madeleine M. Handsley, Zhigang Zhou, Pöschl, E., Erik W. Thompson, Caroline J. Pennington, Lafleur, M. A., Zhou, Zhigang, Cooley, Lindsay S., Pennington, Caroline J., Zhou, Z., Handsley, Madeleine M., Cooley, L. S., Marc A. Lafleur   +22 more
core   +1 more source

Constitutive Expression of the α4 Integrin Correlates with Tumorigenicity and Lymph Node Metastasis of the B16 Murine Melanoma

Neoplasia: An International Journal for Oncology Research, 2010
The lymphatic system plays a critical role in melanoma metastasis, and yet, virtually no information exists regarding the cellular and molecular mechanisms that take place between melanoma cells and the lymphatic vasculature.
Robert B. Rebhun, Hua Cheng, Jeffrey E. Gershenwald, Dominic Fan, Isaiah J. Fidler, Robert R. Langley   +5 more
doaj   +1 more source

Lymphatic Endothelial Cell Plasticity in Development and Disease [PDF]

Physiology, 2017
The lymphatic vasculature is crucial for maintaining tissue-fluid homeostasis, providing immune surveillance and mediating lipid absorption. The lymphatic vasculature is tightly associated with the blood vasculature, although it exhibits distinct morphological and functional features.
Wanshu, Ma, Guillermo, Oliver
openaire   +2 more sources

Single-nuclei multiomic analyses identify human cardiac lymphatic endothelial cells associated with coronary arteries in the epicardium

Cell Reports, 2023
Summary: Cardiac lymphatic vessels play important roles in fluid homeostasis, inflammation, disease, and regeneration of the heart. The developing cardiac lymphatics in human fetal hearts are closely associated with coronary arteries, similar to those in
Stanislao Igor Travisano, Michael R.M. Harrison, Matthew E. Thornton, Brendan H. Grubbs, Thomas Quertermous, Ching-Ling Lien   +5 more
doaj   +1 more source

Digging deeper into lymphatic vessel formation in vitro and in vivo

BMC Cell Biology, 2011
Background Abnormal lymphatic vessel formation (lymphangiogenesis) is associated with different pathologies such as cancer, lymphedema, psoriasis and graft rejection.
Thiry Marc, Foidart Jean-Michel, Lenoir Bénédicte, Maillard Catherine, Lamaye Françoise, Paupert Jenny, Erpicum Charlotte, Bruyère Françoise, Detry Benoit, Noël Agnès   +9 more
doaj   +1 more source

FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake

Molecular Medicine, 2020
Background Therapeutic lymphangiogenesis in an orthotopic lung transplant model has been shown to improve acute allograft rejection that is mediated at least in part through hyaluronan drainage.
Shikshya Shrestha, Woohyun Cho, Benjamin Stump, Jewel Imani, Anthony M. Lamattina, Pierce H. Louis, James Pazzanese, Ivan O. Rosas, Gary Visner, Mark A. Perrella, Souheil El-Chemaly   +10 more
doaj   +1 more source

Lymphatic Endothelial Cell Progenitors in the Tumor Microenvironment [PDF]

, 2020
Tumor lymphatics play a key role in cancer progression as they are solely responsible for transporting malignant cells to regional lymph nodes (LNs), a process that precedes and promotes systemic lethal spread. It is broadly accepted that tumor lymphatic sprouting is induced mainly by soluble factors derived from tumor-associated macrophages (TAMs) and
Sophia, Ran, Lisa, Volk-Draper
openaire   +2 more sources