Results 181 to 190 of about 107,605 (342)

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Role of Transcriptional and Epigenetic Regulation in Lymphatic Endothelial Cell Development. [PDF]

Cells, 2022
La H, Yoo H, Park YB, Thang NX, Park C, Yoo S, Lee H, Choi Y, Song H, Do JT, Hong K.   +10 more
europepmc   +1 more source

Cardiac lymphatic vessels, transport, and healing of the infarcted heart [PDF]

, 2017
Huang, Li-Hao, Lavine, Kory J, Randolph, Gwendalyn J   +2 more
core   +2 more sources

Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease

Advanced Science, EarlyView.
This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang, Yuting Liu, Shufan Jiang, Zilin Fang, Mengda Jiang, Xiaofeng Tao, Tianyi Zhu, Jipeng Li, Sijie Fang, Xuefei Song, Yinwei Li, Jing Sun, Chuanjun Tong, Zhengrun Gao, Huifang Zhou, Xianqun Fan   +15 more
wiley   +1 more source

Effect of the snake venom component crotamine on lymphatic endothelial cell responses and lymph transport. [PDF]

Microcirculation, 2023
Si H, Yin C, Wang W, Davies P, Sanchez E, Suntravat M, Zawieja D, Cromer W.   +7 more
europepmc   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Spatially targeted chemokine exocytosis guides transmigration at lymphatic endothelial multicellular junctions

The EMBO Journal
Migrating cells preferentially breach and integrate epithelial and endothelial monolayers at multicellular vertices. These sites are amenable to forces produced by the migrating cell and subsequent opening of the junctions.
Inam Liaqat, Ida Hilska, Maria Saario, Emma Jakobsson, Marko Crivaro, Johan Peränen, Kari Vaahtomeri   +6 more
doaj   +1 more source

Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor

, 2002
Tatiana V. Petrova
openalex   +2 more sources

Supplementary Data from CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells

, 2023
Tara Karnezis, Rae H. Farnsworth, Nicole C. Harris, Steven P. Williams, Carol Caesar, David J. Byrne, Prad Herle, Maria L. Macheda, Ramin Shayan, You‐Fang Zhang, Sezer Yazar, Simon J. Takouridis, Craig Gérard, Stephen B. Fox, Marc G. Achen, Steven A. Stacker   +15 more
openalex   +1 more source

A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan‐Associated Liver Disease

Advanced Science, EarlyView.
This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Sarah Rezapourdamanab, Mehdi Salar Amoli, Tanmay Mukherjee, Maryam Bagheri, Boeun Hwang, Linqi Jin, Yamini Singh, Sophia Norton, Ashay Vishwas Bongirwar, Shweta Karnik, Lakshmi Prasad Dasi, Reza Avazmohammadi, Rene Romero, Holly D. Bauser‐Heaton, Vahid Serpooshan   +14 more
wiley   +1 more source