Results 211 to 220 of about 105,489 (333)

Lenvatinib Plus Paclitaxel as Second‐Line Therapy for Advanced Gastric Cancer Patients: A Dose Escalation Exploratory Study

open access: yesAdvanced Science, EarlyView.
This study determines the maximum tolerated dose of lenvatinib in combination with paclitaxel as second‐line therapy for advanced gastric cancer patients. A dynamic network biomarker panel associated with patient prognosis and response to treatment is established.
Chenfei Zhou   +8 more
wiley   +1 more source

Vascular endothelial growth factor-C secreted by pancreatic cancer cell line promotes lymphatic endothelial cell migration in an in vitro model of tumor lymphangiogenesis

open access: bronze, 2007
Nobuo Ochi   +8 more
openalex   +2 more sources

Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) and CD99 Are Critical in Lymphatic Transmigration of Human Dendritic Cells [PDF]

open access: bronze, 2011
Martin Torzicky   +6 more
openalex   +1 more source

Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy

open access: yesAdvanced Science, EarlyView.
This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan   +4 more
wiley   +1 more source

Axillary adipose tissue-derived lymphatic endothelial cells exhibit distinct transcriptomic signatures reflecting lymphatic invasion status in breast cancer. [PDF]

open access: yesBreast Cancer Res
Iesato A   +20 more
europepmc   +1 more source

Cancer-associated fibroblast-derived PAI-1 promotes lymphatic metastasis via the induction of EndoMT in lymphatic endothelial cells. [PDF]

open access: yesJ Exp Clin Cancer Res, 2023
Wei WF   +10 more
europepmc   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

open access: yesAdvanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji   +14 more
wiley   +1 more source

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