Vacuolization as a Novel Approach to Cancer Therapy
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak +9 more
wiley +1 more source
Orbital venous lymphatic malformations: case series on minimally invasive treatment approach. [PDF]
Ranjan A, Chhabra AK, Kumar M.
europepmc +1 more source
Unraveling Oral Dysbiosis: Microbial Complexity in Common Oral Diseases
The oral microbiome undergoes dynamic establishment from birth, maturing into a resilient ecosystem. Perturbation of this homeostasis—driven by dietary, immunological, and anatomical factors—triggers dysbiosis, which underpins the pathogenesis of major oral diseases, including dental caries, periodontal disease, salivary gland disorders, oral mucosal ...
Zixi Kang +8 more
wiley +1 more source
A real-world study of sirolimus in the treatment of pediatric head and neck lymphatic malformations. [PDF]
Wang J +13 more
europepmc +1 more source
Organoids: From Bench to Bedside Applications
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li +6 more
wiley +1 more source
Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications
Particle shape is a key design parameter governing biological interactions. Advances in fabrication enable precise control over anisotropy and compartmentalization, allowing modulation of cellular uptake, transport, and biodistribution, ultimately enhancing therapeutic performance. ABSTRACT Polymer geometry is a primary determinant of physical behavior
Francisca G. Perfeito +2 more
wiley +1 more source
Outcome evaluation for the treatment of low flow venous and lymphatic malformations. [PDF]
Moussa RM +5 more
europepmc +1 more source
Improved Bone Conduction and Hearing Outcomes After Stapes Surgery for Otosclerosis
ABSTRACT Objective To evaluate the improvement in bone conduction (BC) thresholds after stapes surgery for otosclerosis, compare the outcomes of surgical techniques, and analyze the short‐ and long‐term results to inform treatment strategies. Methods We retrospectively reviewed data from 173 patients (188 ears) who underwent total stapedectomy, partial
Na Zhang +6 more
wiley +1 more source
Classification, diagnosis, and management of orbital venous-lymphatic malformations: Current state-of-the-art. [PDF]
Tsai YJ, Chao A, Chu YC, Chao AN.
europepmc +1 more source

