Results 101 to 110 of about 709,350 (366)

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Malignant priapism due to penile metastases. Case series and literature review [PDF]

, 2016
Malignant priapism secondary to penile metastases is a rare condition. This term was originally used by Peacock in 1938 to describe a condition of painful induration and erection of the penis due to metastatic infiltration by a neoplasm.
DE DOMINICIS, Carlo, DE LUCA, Francesco, Manzi, Emy, Maurizi, Angela, Ralph, David, Shabbir, Majed, Zacharakis, Evangelos, Zanghì, Antonio   +7 more
core   +2 more sources

Molecular Mechanisms of Lymphatic Metastasis

, 2012
Colorectal cancer (CRC) is the third most common cancer worldwide. Considering the high rate of incidence and mortality of CRC it is critical to determine the mechanisms of its dissemination. Although one of the better characterised tumours the prognosis of patients decreases dramatically when lymphatic metastasis occurs.
Michael Stürzl, R.S. Croner, Vera Schellerer, K. Oeckl, Elisabeth Naschberger, M.C. Langheinrich   +5 more
openaire   +4 more sources

Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer.

Journal of Clinical Investigation, 2019
Patients with bladder cancer (BCa) with clinical lymph node (LN) metastasis have extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN metastasis in BCa.
Changhao Chen, Yuming Luo, Wang He, Yue Zhao, Yao Kong, Hongwei Liu, Guangzheng Zhong, Yuting Li, Jun Li, Jian Huang, Rufu Chen, Tianxin Lin   +11 more
semanticscholar   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Integrin α6‐containing extracellular vesicles promote lymphatic remodelling for pre‐metastatic niche formation in lymph nodes via interplay with CD151

Journal of Extracellular Vesicles
Heterogeneous extracellular vesicles (EVs) from various types of tumours are acknowledged for inducing the formation of pre‐metastatic “niches” in draining lymph nodes (LNs) to promote lymphatic metastasis.
Yan Lin, Hanhao Zheng, Linpei Jia, Yuming Luo, Dingwen Zhang, Mingjie An, Mingrui Pang, Xiayao Diao, Wenjie Li, Jiancheng Chen, Yuanlong Li, Daiyin Liu, Zhicong Liu, Jian Huang, Tianxin Lin, Changhao Chen   +15 more
doaj   +1 more source

Cutaneous metastasis of bladder urothelial carcinoma; A rare conditions

Urology Case Reports, 2022
Cutaneous is an extremely rare metastatic area of bladder urothelial carcinoma. Pure cutaneous metastasis without systemic metastasis is very rare and less than ten cases have been reported in the literature. Our patient had various lymphatic fistulas to
Hakan Öztürk, Selin Yurtsever, Arzum Özer, Çağatay Arslan, Fatma Seher Pehlivan, Aysun Tekeli   +5 more
doaj  

Progress in the Mechanism of Lymphangiogenesis and Lymphatic Metastasis 
of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2021
Lung cancer ranks the first cancer-related morbidity and mortality in China. Tumor metastasis always predicts the poor prognosis for patients. Moreover, lymphatic metastasis is one of the most significant predictors of poor prognosis in patients with non-
Xiayao DIAO, Chao GUO, Shanqing LI
doaj   +1 more source

A Review of Mathematical Models for the Formation of\ud Vascular Networks [PDF]

, 2012
Mainly two mechanisms are involved in the formation of blood vasculature: vasculogenesis and angiogenesis. The former consists of the formation of a capillary-like network from either a dispersed or a monolayered population of endothelial cells ...
Bell, C. G., Preziosi, L., Scianna, M.
core  

The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]

, 2018
Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi, Burgoyne, Paul, Burt, Claire L., Fraser, Alasdair R., Graham, Gerard J., Hansell, Christopher A.H., Hayes, Alan J., Lee, Kit Ming, Macleod, Megan K.L., Medina-Ruiz, Laura, Nibbs, Robert J.B., Pingen, Marieke, Wilson, Gillian J.   +12 more
core   +1 more source