Clinical significance of VEGF-A, -C and -D expression in esophageal malignancies [PDF]
, 2005 Vascular endothelial growth factors ( VEGF)- A, - C and - D are members of the proangiogenic VEGF family of glycoproteins. VEGF-A is known to be the most important angiogenic factor under physiological and pathological conditions, while VEGF-C and VEGF-D
Ahn MJ +48 more
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Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates. [PDF]
, 2019 Tumor metastasis into the central nervous system (CNS) and lymph nodes (LNs) is a major obstacle for effective therapies. Therapeutic monoclonal antibodies (mAb) have revolutionized tumor treatment; however, their efficacy for treating metastatic tumors ...
Chen, Irvin SY +18 more
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B Lymphocytes Promote Lymphogenous Metastasis of Lymphoma and Melanoma
Neoplasia: An International Journal for Oncology Research, 2011 The prognosis of patients with many types of cancers correlates with the degree of metastasis to regional lymph nodes (LNs) and vital organs. However, the mechanisms and route of cancer cell metastasis are still unclear.
Alanna Ruddell +4 more
doaj +1 more source
Investigating the Effects of Shear Stress on the Protein Expression of Lymphatic Endothelial Cells (LECs) [PDF]
, 2018 The lymphatic system plays three main important roles: Its cells are primarily responsible for the immune response of the human body, it represents a separate circulatory system, and it is involved in the transport of select nutrients from the digestive ...
Hussein, Tawfik M
core +1 more source
Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis. [PDF]
, 2018 Tumour cells are subjected to evolutionary selection pressures during progression from initiation to metastasis. We analysed the clonal evolution of squamous skin carcinomas induced by DMBA/TPA treatment using the K5CreER-Confetti mouse and stage ...
Balmain, Allan +4 more
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Recent advances in lymphatic targeted drug delivery system for tumor metastasis
Cancer Biology & Medicine, 2014 The lymphatic system has an important defensive role in the human body. The metastasis of most tumors initially spreads through the surrounding lymphatic tissue and eventually forms lymphatic metastatic tumors; the tumor cells may even transfer to other ...
Xiao-Yu Zhang, Wei-Yue Lu
doaj +1 more source
Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy [PDF]
, 2011 This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network ...
Cai, Y +6 more
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Breast cancer metastasis and the lymphatic system
Oncology Letters, 2015 Breast cancer remains the leading cause of cancer mortality worldwide, despite a significant decline in death rates due to early detection. The majority of cancer mortalities are due to the metastasis of tumor cells to other organs. Metastasis or tumor cell dissemination occurs via the hematogenous and lymphatic systems.
Munazzah, Rahman, Sulma, Mohammed
openaire +3 more sources
Significance of risk factor analysis and dissection for station 4L lymphatic metastasis in left lung cancer: a systematic review and meta-analysis [PDF]
, 2021 Chu-Xu Wang +5 more
openalex +1 more source
Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis [PDF]
, 2016 Human papillomavirus induced (HPV+) cancer incidence is rapidly rising, comprising 60–80% of oropharyngeal squamous cell carcinomas (OPSCCs); while rare, recurrent/metastatic disease accounts for nearly all related deaths.
Coppock, Joseph D +8 more
core +2 more sources