Results 121 to 130 of about 709,350 (366)

Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis [PDF]

, 2016
Human papillomavirus induced (HPV+) cancer incidence is rapidly rising, comprising 60–80% of oropharyngeal squamous cell carcinomas (OPSCCs); while rare, recurrent/metastatic disease accounts for nearly all related deaths.
Coppock, Joseph D, Lee, John H, Lee, Kimberly M, Onken, Michael D, Spanos, William C, Uppaluri, Ravindra, Vermeer, Daniel W, Vermeer, Paola D, Zeng, Erliang   +8 more
core   +2 more sources

Breast cancer metastasis and the lymphatic system

Oncology Letters, 2015
Breast cancer remains the leading cause of cancer mortality worldwide, despite a significant decline in death rates due to early detection. The majority of cancer mortalities are due to the metastasis of tumor cells to other organs. Metastasis or tumor cell dissemination occurs via the hematogenous and lymphatic systems.
Munazzah Rahman, Sulma I. Mohammed
openaire   +4 more sources

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Metallopanstimulin as a marker for head and neck cancer [PDF]

, 2004
BACKGROUND: Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC).
A Agrawal, A Dietz, BC Stack Jr, CS Hollenbeak, DJ Santa Cruz, DR Ganger, DR Ganger, E Tartour, H Kasai, H Naora, H Quon, IG Wool, IG Wool, JA Fernandez-Pol, JA Fernandez-Pol, JA Fernandez-Pol, JA Fernandez-Pol, JA Fernandez-Pol, JT Wadsworth, JT Wadsworth, M Schmidt, PA Rockledge, RR Million, TN Teknos, VJ Lowe, WJ Lee, Y Atsuta, YL Chan, YL Chan   +28 more
core   +4 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Risk factors for lymphatic and hematogenous metastasis after diagnosis of cutaneous Melanoma in Taiwan

Journal of the Formosan Medical Association, 2022
Background: Risk factors of lymphatic and hematogenous metastasis in cutaneous melanoma remained unclear in Asian population. This study aimed to identify clinical and histopathological factors to predict metastatic pathways in cutaneous melanoma in ...
Che-Chia Hsu, Tung-Lin Lee, Ming-Hsien Lin, Yi-Hua Liao, Jau-Yu Liau, Yi-Shuan Sheen   +5 more
doaj  

Recent advances in lymphatic targeted drug delivery system for tumor metastasis

Cancer Biology & Medicine, 2014
The lymphatic system has an important defensive role in the human body. The metastasis of most tumors initially spreads through the surrounding lymphatic tissue and eventually forms lymphatic metastatic tumors; the tumor cells may even transfer to other ...
Xiao-Yu Zhang, Wei-Yue Lu
doaj   +1 more source

Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]

, 2017
Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C., Pestell, Richard G., Shupp, Alison   +2 more
core   +2 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

VEGF-D(ilated) Lymphatics as Gateways to Metastasis [PDF]

Cancer Cell, 2012
VEGF-C and VEGF-D have been implicated in lymphatic metastasis, mainly as inducers of new intra/peritumoral capillary lymphatics. In this issue of Cancer Cell, Karnezis and colleagues challenge this notion and demonstrate that tumor-derived VEGF-D promotes metastasis by causing prostaglandin-dependent dilation of collecting lymphatics outside of the ...
openaire   +3 more sources