Results 71 to 80 of about 22,605,370 (372)

Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS

open access: yesFrontiers in Neuroscience, 2021
The classic concept of the absence of lymphatic vessels in the central nervous system (CNS), suggesting the immune privilege of the brain in spite of its high metabolic rate, was predominant until recent times.
Gianfranco Natale   +7 more
doaj   +1 more source

GIANT CYSTIC HYGROMA COLLI IN AN ADULT- A RARE CASE REPORT [PDF]

open access: yes, 2012
Cystic hygroma (lymphangioma) is often a benign congenital malformation of the lymphatic system that occurs as a result of sequestration or obstruction of lymphatic vessels. Theselesions are usually discovered in infant or children younger than two years
Karunakaran, Anupama   +1 more
core   +1 more source

Lymphangiogenesis: from the pig embryos to cancer [PDF]

open access: yes, 2008
The discovery and the comprehension of lymphatic vessels suffered several historical delays and setbacks. The inherent anatomical problems slowed down the precise identification of the lymphatic system during the development of medical science.
Duarte, Maria   +2 more
core   +3 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

open access: yesFEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi   +5 more
wiley   +1 more source

Prognostic Significance of Canine Mammary Tumor Histologic Subtypes: An Observational Cohort Study of 229 Cases [PDF]

open access: yes, 2017
Histopathology is considered the gold standard diagnostic method for canine mammary tumors. In 2011, a new histologic classification for canine mammary tumors was proposed.
Berlato, Davide   +3 more
core   +1 more source

Regulation of Immune Function by the Lymphatic System in Lymphedema

open access: yesFrontiers in Immunology, 2019
The lymphatic vasculature has traditionally been thought to play a passive role in the regulation of immune responses by transporting antigen presenting cells and soluble antigens to regional lymph nodes.
Raghu P. Kataru   +6 more
semanticscholar   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Investigating the Effects of Shear Stress on the Protein Expression of Lymphatic Endothelial Cells (LECs) [PDF]

open access: yes, 2018
The lymphatic system plays three main important roles: Its cells are primarily responsible for the immune response of the human body, it represents a separate circulatory system, and it is involved in the transport of select nutrients from the digestive ...
Hussein, Tawfik M
core   +1 more source

Is There a Cerebral Lymphatic System? [PDF]

open access: yesStroke, 2013
The brain is unique among virtually all somatic organs in its lack of a conventional lymphatic vasculature.1–3 In the periphery, the lymphatic circulation facilitates the clearance of extracellular proteins and excess fluid from the interstitium, a role critical to tissue homeostasis and function.4,5 Yet within the brain, despite its complex ...
Jeffrey J, Iliff, Maiken, Nedergaard
openaire   +3 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

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