Results 51 to 60 of about 181,912 (295)

Lymphatic vascular morphogenesis in development, physiology, and disease

, 2011
The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the
Amélie Sabine, Petrova, T.V., Stefan Schulte-Merker, Sabine, A., Schulte-Merker, S., Petrova, T. V., Tatiana V. Petrova   +6 more
core   +1 more source

Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium

Frontiers in Physiology, 2023
Enhancing our understanding of lymphatic anatomy from the microscopic to the anatomical scale is essential to discern how the structure and function of the lymphatic system interacts with different tissues and organs within the body and contributes to ...
Dhruv Singhal, Katy Börner, Elliot L. Chaikof, Michael Detmar, Maija Hollmén, Jeffrey J. Iliff, Maxim Itkin, Taija Makinen, Guillermo Oliver, Timothy P. Padera, Ellen M. Quardokus, Andrea J. Radtke, Hiroo Suami, Griffin M. Weber, Ilsa I. Rovira, Selen C. Muratoglu, Zorina S. Galis   +16 more
doaj   +1 more source

Meningeal Lymphatics: An Immune Gateway for the Central Nervous System

Cells, 2021
The recent (re)discovery of the meningeal lymphatic system has opened new theories as to how immune cells traffic and interact with the central nervous system (CNS).
Gabriel A. Tavares, Antoine Louveau
doaj   +1 more source

Review on the Lymphatic Vessels in the Dental Pulp

Biology, 2021
Despite many studies, opinions on the lymphatic system of the teeth are still incompatible. Studies using light and electron microscopy and directly using methods such as a radioisotope (radionuclide) scan and interstitial fluid pressure measurement ...
Kamila Wiśniewska, Zbigniew Rybak, Maria Szymonowicz, Piotr Kuropka, Maciej Dobrzyński   +4 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Regulation of Lymphatic Vasculature by Extracellular Matrix

, 2013
The extracellular matrix (ECM) is a complex but highly organized network of macromolecules with different physical, biochemical, and mechanical properties.
Lutter, Sophie, Mäkinen, Taija,, Taija Makinen, Sophie Lutter   +3 more
core   +1 more source

Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes [PDF]

, 2016
OBJECTIVE: The lymphatic vascular system exerts major physiological functions in the transport of interstitial fluid from peripheral tissues back to the blood circulation and in the trafficking of immune cells to lymph nodes.
Sesartic, M, Halin, C, Watson, Steve P, Russo, Erica, Bachmann, SB, Detmar, Michael, Buckley, CD, Bianchi, Roberta, Proulx, ST, Detmar, M, Buckley, Christopher D, Halin, Cornelia, Proulx, Steven T, Smaadahl, N, Bianchi, R, Bachmann, Samia B, Watson, Steve P; id_orcid, Russo, E, Watson, SP, Sesartic, Marko, Smaadahl, Nora, Buckley, Christopher D.   +21 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source