Results 91 to 100 of about 273,500 (290)

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke   +3 more
wiley   +1 more source

Modeling and Characterization of Lymphatic Vessels Using a Lumped Parameter Approach [PDF]

, 2013
The lymphatic system is responsible for several vital roles in human body, one of which is maintaining fluid and protein balance. There is no central pump in the lymphatic system and the transport of fluid against gravity and adverse pressure gradient is
Jamalian Ardakani, Seyedeh Samira 1987-
core  

Studies of the Tumor-Vasculature Interface : Role of TGF-beta 1-induced Epithelial to Mesenchymal Transition [PDF]

, 2013
Tumor metastasis is a complex multistep process. Among key steps that occur during metastatic spread are acquisition of tumor cell motility, intravasation of tumor cells into blood or lymphatic vessels and extravasation of tumor cells at distal sites ...
Pang, Mei-Fong
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Physical therapies for reducing and controlling lymphoedema of the limbs. [PDF]

, 2008
Background Lymphoedema is the accumulation of excess fluid in the body caused by obstruction of the lymphatic drainage mechanisms. Management involves decongesting the reduced lymphatic pathways in order to reduce the size of the limb.
Ahmed, Andersen, Badger, Badger, Bergan, Bertelli, Carroll, Didem, Dini, Erickson, Foldi, Harris, Hornsby, Irdesel, Johansson, Johansson, Kligman, Levick, McKenzie, McNeely, Moffatt, Mortimer, Moseley, Petrek, Sitzia, Sitzia, Szuba, Szuba, Tobin, Wilburn, Williams   +30 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2. [PDF]

, 2015
The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show
Adams, R.H., Agalarov, Y., Bibb, J.A., Demir, C.S., Hager, B., Kiefer, F., Liebl, J., Miura, N., Moser, M., Petrova, T.V., Vollmar, A.M., Zahler, S., Zhang, S.   +12 more
core   +2 more sources

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature.

PLoS ONE, 2013
Vascular endothelial growth factor receptor 2 (VEGFR2) is highly expressed by lymphatic endothelial cells and has been shown to stimulate lymphangiogenesis in adult mice. However, the role VEGFR2 serves in the development of the lymphatic vascular system
Michael T Dellinger, Stryder M Meadows, Katherine Wynne, Ondine Cleaver, Rolf A Brekken   +4 more
doaj   +1 more source

Prostate lymphoscintigraphy and radio-guided surgery for sentinel lymph node identification in prostate cancer - Technique and results of the first 350 cases [PDF]

, 2003
Introduction: Having in mind the promising results of lymphoscintigraphy and intraoperative gamma probe application for the detection of sentinel lymph nodes (SLN) in malignant melanoma, breast and penis cancer, we tried to identify the SLN in prostate ...
Graf, Gerhard, Hamm, Michael, Harzmann, Rolf, Heidenreich, Peter, Keil, Mathias, Vogt, Harry, Wawroschek, Friedhelm, Weckermann, Dorothea, Wengenmair, Hermann   +8 more
core   +1 more source