Results 121 to 130 of about 964,971 (353)

VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption

EMBO Molecular Medicine, 2015
Vascular endothelial growth factor C (VEGF‐C) binding to its tyrosine kinase receptor VEGFR‐3 drives lymphatic vessel growth during development and in pathological processes.
H. Nurmi, P. Saharinen, G. Zarkada, Wei Zheng, M. Robciuc, K. Alitalo   +5 more
semanticscholar   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Clinical overview on RASopathies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 414-424, December 2022., 2022
Abstract RASopathies comprise a group of clinically overlapping developmental disorders caused by genetic variations affecting components or modulators of the RAS‐MAPK signaling cascade, which lead to dysregulation of signal flow through this pathway.
Martin Zenker
wiley   +1 more source

Tuning the Morphological Properties of Granular Hydrogels to Control Lymphatic Capillary Formation

Advanced Materials Interfaces, EarlyView.
Tuning the morphological properties of granular hydrogels is essential to generate robust lymphatic capillary networks that express key lymphatic gene and protein markers. The study demonstrates that 3D in vitro lymphatic tube formation is controlled not by the mechanical properties of the gel, but by the pore size and topology (periodicity) of the gel
Daniel Montes, Sanjoy Saha, Angela Taglione, Donghyun Paul Jeong, Liao Chen, Fei Fan, Hsueh‐Chia Chang, Donny Hanjaya‐Putra   +7 more
wiley   +1 more source

Limfangiogenesis sebagai jalur alternatif metastasis kanker

Lymphangiogenesis as an alternative pathway for cancer metastasis

Jurnal Kedokteran Gigi Universitas Padjadjaran, 2016
Pendahuluan: Metastasis merupakan salah satu sifat kanker yang dapat terjadi melalui berbagai cara yaitu melalui rongga tubuh, melalui pembuluh limfatik, dan melalui pembuluh darah. Pembuluh limfatik merupakan jalur penting dalam metastasis kanker karena
Pudji Handayani, Tadeus Arufan Jasrin, Sunardhi Widyaputra   +2 more
doaj   +1 more source

Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction

PLoS Pathogens, 2015
The host lymphatic network represents an important conduit for pathogen dissemination. Indeed, the lethal human pathogen group A streptococcus has a predilection to induce pathology in the lymphatic system and draining lymph nodes, however the underlying
N. Lynskey, Suneale Banerji, L. A. Johnson, Kayla A. Holder, Mark Reglinski, P. Wing, D. Rigby, D. Jackson, S. Sriskandan   +8 more
semanticscholar   +1 more source

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source

A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research

PLoS ONE, 2015
The lymphatic vascular system plays an active role in immune cell trafficking, inflammation and cancer spread. In order to provide an in vivo tool to improve our understanding of lymphatic vessel function in physiological and pathological conditions, we ...
R. Bianchi, Á. Teijeira, Steven T. Proulx, A. Christiansen, C. Seidel, T. Rülicke, Taija Mäkinen, R. Hägerling, C. Halin, M. Detmar   +9 more
semanticscholar   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2

Nature Communications, 2015
The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show
J. Liebl, Siwei Zhang, M. Moser, Yan Agalarov, Cansaran Saygili Demir, B. Hager, J. Bibb, R. Adams, F. Kiefer, N. Miura, T. Petrova, A. Vollmar, S. Zahler   +12 more
semanticscholar   +1 more source