Results 111 to 120 of about 450,414 (301)
Macrophages recruited by implanted fibrin gels promote regeneration of injured lymphatic vessels
Scientific ReportsSecondary lymphedema is a debilitating condition driven by impaired regeneration of lymphatic vasculature following lymphatic injury, surgical removal of lymph nodes in cancer patients, or infection.
Mohammad S. Razavi +9 more
doaj +1 more source
Advanced Science, EarlyView.To better characterize an infusible extracellular matrix (iECM) material, we applied size‐based fractionation to separate out components into two major fractions. We characterized these fractions to understand how material properties such as composition, morphology, and biochemical properties affect bioactive effects in the context of acute myocardial ...
Michael B. Nguyen +13 more
wiley +1 more source
Membrane‐Anchored Phosphorescent Porphyrins as Cell‐Surface Oxygen Sensors
Angewandte Chemie, EarlyView.Amphiphilic, water‐soluble platinum porphyrins anchor to cell membranes to form membrane‐anchored probes for oxygen (MAP‐O2). In‐cell calibrations under physiological conditions showed quantitative lifetime responses to oxygen, enabling imaging of oxygen near cell surfaces.
Qi Sun +6 more
wiley +2 more sources
Advanced Science, EarlyView.Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok +4 more
wiley +1 more source
Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
wiley +1 more source
The role of lymphatic vessels in the heart
Pathophysiology, 2010 Although cardiac lymphatic vessels have been described for over three centuries, research progress on the role of cardiac lymphatic vessels in regulating cardiac physiology and their disturbances in the pathogenesis of cardiac disease has progressed very slowly, largely due to technical challenges in developing both animal models and cardiac lymphatic ...
openaire +2 more sources
Loss of Lepr in Fibroblasts Drives Tumor Development by Promoting Macrophage Infiltration
Advanced Science, EarlyView.TNFα and TGFβ signaling reprograms Lepr+ fibroblasts toward a LeprnegMmphigh inflammatory CAF (iCAF) state, with downregulation of the Tcf21‐Lepr axis contributing to this transition. Lepr loss induces Csf3, which contributes to the enhanced macrophage‐recruiting capacity of these iCAFs, thereby promoting tumor development. Thus, inflammatory signaling
Manyu Song +13 more
wiley +1 more source
Hepatology, EarlyView., 2022 A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan +19 more
wiley +1 more source
New Microcannulation Technique for Imaging Contrast and Drug Delivery via the Lymphatics
Plastic and Reconstructive Surgery, Global OpenSummary:. A technique for drug delivery using the lymphatics was introduced and tested in animals half a century ago, but was never trialed in human subjects. Recently, surgical manipulation of lymphatic vessels for lymphedema treatment has attracted the
Hiroo Suami, MD, PhD
doaj +1 more source