Results 91 to 100 of about 403,412 (304)

Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos [PDF]

, 2008
We previously identified apoptosis stimulating protein of p53 (Aspp1) as an endothelial-specific gene functioning in mouse embryogenesis. To investigate the in vivo role of Aspp1, we generated Aspp1 knockout mice by targeted disruption.
Sano, Keigo, Suda, Toshio, Morisada, Toru, Hirashima, Masanori, Murakami, Kyoko, Rossant, Janet   +5 more
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Kynurenic acid mediates epicardial fat-induced lymphatic metabolic dysfunction in atrial fibrillation

Nature Communications
Atrial fibrillation represents a prevalent cardiac arrhythmia whose pathogenic mechanisms remain incompletely understood. Here, we identify impaired atrial lymphangiogenesis as a critical determinant in atrial fibrillation pathogenesis. Analysis of human
Masaki Takahashi, Ichitaro Abe, Naofumi Yoshida, Daisuke Katoh, Daishi Fujita, Shunsuke Goto, Hirochika Yamasaki, Toshiyuki Ko, Yue Jiang, Yu He, Shinji Ito, Taisuke Harada, Masayuki Takano, Hiroki Sato, Hidekazu Kondo, Akira Fukui, Yasushi Teshima, Hidenori Sako, Keisuke Ohta, Shinji Miyamoto, Toshimasa Yamauchi, Seitaro Nomura, Norihiko Takeda, Issei Komuro, Naohiko Takahashi   +24 more
doaj   +1 more source

Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival

BMC Cancer, 2001
Background We assessed the nm23-H1 gene product expression and its relationship with lymphatic and blood vessel invasion in patients with esophageal squamous cell carcinoma.
Shimizu Tetsuya, Maeda Masayuki, Edagawa Masao, Matsuzaki Yasunori, Ayabe Takanori, Tomita Masaki, Hara Masaki, Onitsuka Toshio   +7 more
doaj   +1 more source

Lymphatic Vessels

, 2008
Lymphatic vessels are the lymphatic capillaries, collecting vessels, and ducts that form an integral part of the one-way, open-ended circulatory system known as the lymphatic system. In addition to lymphatic vessels, the lymphatic system consists of lymph nodes and other lymphoid organs.
openaire   +2 more sources

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2 [PDF]

, 2015
The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show
Zhang, S., Petrova, T.V., Zhang, Siwei, Demir, C., Liebl, J., Moser, M., Bibb, J., Adams, R., Demir, Cansaran Saygili, Vollmar, A.M., Vollmar, A., Agalarov, Y., Moser, Markus, Bibb, James A., Petrova, Tatiana V., Hager, B., Zahler, Stefan, Kiefer, Friedemann, Bibb, J.A., Adams, R.H., Miura, N., Petrova, T., Miura, Naoyuki, Liebl, Johanna, Vollmar, Angelika M., Zahler, S., Agalarov, Yan, Hager, Bianca, Kiefer, F., Demir, C.S., Adams, Ralf H.   +30 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source