Results 71 to 80 of about 50,398 (261)

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

open access: yesAdvanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui   +9 more
wiley   +1 more source

Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival

open access: yesBMC Cancer, 2001
Background We assessed the nm23-H1 gene product expression and its relationship with lymphatic and blood vessel invasion in patients with esophageal squamous cell carcinoma.
Shimizu Tetsuya   +7 more
doaj   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano   +10 more
wiley   +1 more source

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

open access: yesNature Communications, 2018
VEGF-C is a key regulator of lymphatic development. Here, Zhang et al. show that while complete loss of its receptor VEGFR3 results in vessel hypoplasia, mosaic loss of VEGFR3 leads to hyperplasia through induction of cell proliferation in neighboringnon-
Yan Zhang   +6 more
doaj   +1 more source

On the import and office of the Lymphatic Vessels [PDF]

open access: yesThe American Journal of the Medical Sciences
Abstract That absorption is the special office of the lymphatic vessels was, until very lately, a universally received doctrine in physiology: but it is now admitted that if they exercise this faculty, it can be only to an inconsiderable extent; and physiologists of high authority have even denied that they possess any absorbing power
openaire   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

open access: yesAdvanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li   +8 more
wiley   +1 more source

Mechanical feedback mechanisms in a multiscale sliding filament model of lymphatic muscle pumping

open access: yesApplications in Engineering Science
The lymphatic system maintains bodily fluid balance by returning interstitial fluid to the venous system. Flow can occur through a combination of extrinsic pumping, due to forces from surrounding tissues, and intrinsic pumping involving contractions of ...
Peter Y. Xie   +7 more
doaj   +1 more source

Optimal Indication of D3 Lymph Node Dissection for Non‐Metastatic Colon Cancers by Tumor Stages: Evaluation of Therapeutic Value Index for Each Lymph Node Station

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aims To explore the therapeutic impact of D3 lymph node dissection for non‐metastatic colon cancers, evaluating the therapeutic value index for each lymph node station according to surgical stages. Methods Consecutive patients with surgical Stage I–III colon and rectosigmoid cancer who underwent curative resection between January 2003 and ...
Akira Ouchi   +9 more
wiley   +1 more source

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino   +4 more
wiley   +1 more source

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