Results 71 to 80 of about 450,414 (301)
Advanced Science, EarlyView.A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao +9 more
wiley +1 more source
Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2 [PDF]
, 2015 The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show
Zhang, S. +43 more
core +1 more source
Advanced Science, EarlyView.Non‐invasively quantitative Raman imaging with stacking‐induced charge transfer‐enhanced Raman scattering (SICTERS) enables accurate measurement of concentrations and pharmacokinetic modeling of lymphatic transport of micelles in mice. This platform allows dynamic analysis of nanoparticle transport and underpins the design of effective lymph node ...
Yunlu Li +6 more
wiley +1 more source
Pkd1 Regulates Lymphatic Vascular Morphogenesis during Development
Cell Reports, 2014 Lymphatic vessels arise during development through sprouting of precursor cells from veins, which is regulated by known signaling and transcriptional mechanisms. The ongoing elaboration of vessels to form a network is less well understood.
Baptiste Coxam +15 more
doaj +1 more source
Pathophysiology of aged lymphatic vessels
Aging, 2019 Lymphatic vessels maintain body homeostasis by recirculation of fluid and cells. Cell senescence induces lymphatic dysfunction. Impaired contractile function is caused by low muscle cell investiture and decrease of nitric oxide in aged lymphatic collectors, leading to poor drainage of lymph.
Shang, Tongyao +3 more
openaire +2 more sources
Changes in the desmosomes of lymphatic vessel endothelial cells as shown by electron microscopy.
, 2013 (a) Desmosomes in the normal type. In a three-dimensional structure, they adhere to the adjacent lymphatic vessel endothelial cells. Bar = 2 µm. (a’) Magnified image. Bar = 2 µm.
Takeshi Todokoro (314536) +13 more
core +1 more source
Advanced Science, EarlyView.VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho +6 more
wiley +1 more source
Current Issues in Molecular BiologyRheumatoid arthritis (RA) is sustained not only by immune activation within the synovium but also by dysfunction of the lymphatic network that normally clears interstitial fluid, inflammatory mediators, and leukocytes migrating from inflamed tissues ...
Mi Yang +4 more
doaj +1 more source
Lymphatic vessel remodeling and invasion in pancreatic cancer progressionResearch in context
EBioMedicine, 2019 Background: The lymphatic system is involved in metastasis in pancreatic cancer progression. In cancer staging, lymphatic spread has been used to assess the invasiveness of tumor cells.
Chia-Ning Shen +14 more
doaj +1 more source
DeepLNM: A Multimodal Model for Predicting Lymph Node Metastasis in Colorectal Cancer
Advanced Science, EarlyView.Traditional diagnosis may miss positive LNM cases, and pathologists face a workload; therefore, we develop DeepLNM, a multimodal model that predicts lymph node metastasis in colorectal cancer from H&E WSIs, CT images, and text. DeepLNM is robust across internal, external, and prospective cohorts and, in a user study, improves diagnostic accuracy while ...
Zhengyu Zhang +24 more
wiley +1 more source