Results 131 to 140 of about 964,971 (353)

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity

Development, 2017
Tissue fluid drains through blind-ended lymphatic capillaries, via smooth muscle cell (SMC)-covered collecting vessels into venous circulation. Both defective SMC recruitment to collecting vessels and ectopic recruitment to lymphatic capillaries are ...
Yixin Wang, Yi Jin, M. Mäe, Yang Zhang, H. Ortsäter, C. Betsholtz, Taija Mäkinen, Lars Jakobsson   +7 more
semanticscholar   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Sentinel Lymph Node Biopsy in Breast Cancer: Predictors of Axillary and Non-Sentinel Lymph Node Involvement

Balkan Medical Journal, 2013
Background: Sentinel lymph node biopsy is a standard method for the evaluation of axillary status in patients with T1-2N0M0 breast cancers. Aims: To determine the prognostic significance of primary tumour-related clinico-histopathological factors on ...
Hakan Postacı, Baha Zengel, Ülkem Yararbaş, Adam Uslu, Nuket Eliyatkın, Göksever Akpınar, Fevzi Cengiz, Raika Durusoy   +7 more
doaj   +1 more source

Microcirculation-on-a-Chip: A Microfluidic Platform for Assaying Blood- and Lymphatic-Vessel Permeability

PLoS ONE, 2015
We developed a microfluidic model of microcirculation containing both blood and lymphatic vessels for examining vascular permeability. The designed microfluidic device harbors upper and lower channels that are partly aligned and are separated by a porous
Miwa Sato, Naoki Sasaki, M. Ato, S. Hirakawa, Kiichi Sato, Kae Sato   +5 more
semanticscholar   +1 more source

DNA Origami‐Cyanine Nanocomplex for Precision Imaging of KRAS‐Mutant Pancreatic Cancer Cells

Advanced Science, EarlyView.
DNA origami‐cyanine (Do‐Cy) nanocomplexes are synthesized to selectively image KRAS‐mutant pancreatic cancer cells in the highly desmoplastic tumors. This study shows that the Do‐Cy nanocomplexes are preferentially internalized by cancer cells over other stroma cells via KRAS‐dependent macropinocytosis.
Hye‐ran Moon, Yancheng Du, Sae Rome Choi, Seongmin Seo, Cih Cheng, Bennett D. Elzey, Jong Hyun Choi, Bumsoo Han   +7 more
wiley   +1 more source

How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis?

World Journal of Surgical Oncology, 2007
Background Lymphatic vessels are major routes for metastasis in head and neck squamous cell carcinoma (HNSCC), but lymphatic endothelial cells (LECs) are difficult to recognize in tumor histological sections. D2-40 stains podoplanin, a molecule expressed
Mercante Ana, Curioni Otávio, de Carvalho Marcos, Pinheiro Céline, Oliveira Tiago, Longatto Filho Adhemar, Schmitt Fernando C, Gattás Gilka JF   +7 more
doaj   +1 more source

CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability.

Journal of Clinical Investigation, 2016
Lymphatic collecting vessels direct lymph into and from lymph nodes (LNs) and can become hyperpermeable as the result of a previous infection. Enhanced permeability has been implicated in compromised immunity due to reduced flow of lymph and immune cells
Stoyan Ivanov, Joshua P. Scallan, Ki-Wook Kim, Kathrin Werth, M. W. Johnson, B. Saunders, Peter L. Wang, Emma L. Kuan, A. Straub, Melissa Ouhachi, Erica G. Weinstein, Jesse W. Williams, Carlos G Briseño, M. Colonna, B. Isakson, E. Gautier, R. Förster, M. Davis, B. Zinselmeyer, G. Randolph   +19 more
semanticscholar   +1 more source

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB Signaling

Advanced Science, EarlyView.
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran, Yideul Jeong, Suwoo Kim, Ji Eun Yeom, Jinwoo Lee, Wonhwa Lee, Gyu‐Un Bae, Jong‐Sun Kang   +7 more
wiley   +1 more source

Histological insight into the hepatic tissue of the Nile monitor (Varanus niloticus) [PDF]

arXiv, 2018
The liver of reptiles is considered an important study model for the interaction between environment and hepatic tissue. Little is known about the histology of the liver of reptiles. The aim of the current study was to elucidate the histological architecture of the liver of the Nile monitor (Varanus niloticus).
arxiv