Results 181 to 190 of about 50,153 (264)

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Lymphatic vessel network injury reduces local tumor control despite preservation of the tumor-draining lymph node. [PDF]

Sci Rep
Liebman LN, Shen Y, Buchwald ZS, Nepiyushchikh Z, Qi Z, García AJ, Dixon JB.   +6 more
europepmc   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source

Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis. [PDF]

Front Immunol
Li J, Liang YB, Wang QB, Li YK, Chen XM, Luo WL, Lakang Y, Yang ZS, Wang Y, Li ZW, Ke Y.   +10 more
europepmc   +1 more source

Fetal anatomy of peripheral lymphatic vessels: a D2‐40 immunohistochemical study using an 18‐week human fetus (CRL 155 mm) [PDF]

, 2010
Zhe Wu Jin, Takuo Nakamura, Hee Chul Yu, Wataru Kimura, Gen Murakami, Baik Hwan Cho   +5 more
openalex   +1 more source

Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, EarlyView.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation [PDF]

, 2010
Emma Gordon, Sujata Rao, Jeffrey W. Pollard, Stephen L. Nutt, Richard A. Lang, Natasha L. Harvey   +5 more
openalex   +1 more source

CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer

Cancer Communications, EarlyView.
Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang, Guoshu Bi, Xiaolong Huang, Zhijie Xu, Yiwei Huang, Yunyi Bian, Guangyao Shan, Wei Guo, Yuanliang Yan, Qihai Sui, Xiaodong Yang, Zhencong Chen, Tao Lu, Huan Zhang, Qun Wang, Wei Jiang, Cheng Zhan   +16 more
wiley   +1 more source

Fibroblasts facilitate lymphatic vessel formation in transplanted heart. [PDF]

Theranostics
Gong H, Wang T, Sun X, Zhang Y, Qiu Y, Sun W, Zhang Y, Teng P, Hu Y, Hu X, Ma L, Xu Q, Zhao H.   +12 more
europepmc   +1 more source

Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development [PDF]

, 2010
Fu‐Jung Lin, Xinpu Chen, Jun Qin, Young‐Kwon Hong, Ming‐Jer Tsai, Sophia Y. Tsai   +5 more
openalex   +1 more source