Results 121 to 130 of about 1,203,096 (351)

Effects of ionizing radiation on normal and tumor-associated lymphatic vessels [PDF]

, 2007
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Nuclear Science and Engineering, 2007."June 2007."Includes bibliographical references (p. 37-43).Lymphatic vessels play a crucial role in both the pathophysiology of tumors and in the spread ...
Lobo, Jennifer D
core  

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice [PDF]

, 2013
Reverse cholesterol transport (RCT) refers to the mobilization of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal excretion. Little is known about how HDL-C leaves peripheral tissues to reach plasma.
Bittman, Robert, Chen, Shu-Hsia, Fulp, Brian, Gautier, Emmanuel, Kreisel, Daniel, Li, Wenjun, Martel, Catherine, Platt, Andrew M, Randolph, Gwendalyn J, Sorci-Thomas, Mary G, Swartz, Melody A, Tall, Alan R, Thomas, Michael J, Westerterp, Marit   +13 more
core   +5 more sources

Biofabrication of Endothelialized, Intrinsically Vascularized 3D‐Printed Recombinant Spider Silk Scaffolds

Advanced Healthcare Materials, EarlyView.
This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold, Stefanie Heltmann‐Meyer, Xuen J. Ng, Thomas Scheibel, Tobias Fey, Harald Wajant, Carol Geppert, Andreas Arkudas, Dominik Steiner, Raymund E. Horch   +9 more
wiley   +1 more source

RET mutation and increased angiogenesis in medullary thyroid carcinomas [PDF]

, 2016
Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis.
Acquaviva, Giorgia, Boichard, Amélie, Casadei, Gian Piero, Checquolo, Saula, Colato, Chiara, de Biase, Dario, Durante, Cosimo, Ferdeghini, Marco, Filetti, Sebastiano, Pecce, Valeria, Rhoden, Kerry, Rosignolo, Francesca, Russo, Diego, Sponziello, Marialuisa, Tallini, Giovanni, Verrienti, Antonella, Visani, Michela   +16 more
core   +1 more source

Tumor-Associated Lymphatic Vessels Upregulate PDL1 to Inhibit T-Cell Activation

Frontiers in Immunology, 2017
Tumor-associated lymphatic vessels (LVs) play multiple roles during tumor progression, including promotion of metastasis and regulation of antitumor immune responses by delivering antigen from the tumor bed to draining lymph nodes (LNs).
L. Dieterich, K. Ikenberg, T. Cetintas, Kübra Kapaklikaya, Cornelia Hutmacher, M. Detmar   +5 more
semanticscholar   +1 more source

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early Rheumatoid Arthritis: an observational study. [PDF]

, 2015
INTRODUCTION: Neovascularization contributes to the development of sustained synovial inflammation in the early stages of Rheumatoid Arthritis. Ultrasound (US) provides an indirect method of assessing synovial blood flow and has been shown to correlate ...
AE Koch, AE Koch, Alessandra Marrelli, Arti Mahto, AW Mould, Costantino Pitzalis, Debasish Pyne, E Bodolay, Frances Humby, J Holash, J Holash, K Polzer, Lu Zou, M Andersen, M Raica, M Walther, M Walther, Maria DiCicco, Michele Bombardieri, Nora Ng, P Haiko, PP Tak, Rebecca E Hands, S Kelly, S Lee, Stephen Kelly, Sudeh Riahi, U Fiocco, U Fiocco, V Krenn, WA Schmidt, Y Jing, Y Xu, Z Szekanecz   +33 more
core   +2 more sources

Multiple roles of lymphatic vessels in tumor progression.

Current Opinion in Immunology, 2018
Sentinel lymph node metastasis is a prognostic indicator for systemic tumor spread in many types of cancers, and tumor lymphangiogenesis correlates with reduced survival. Consequently, lymphatic vessels have been suggested to promote tumor progression in
Qiaoli Ma, L. Dieterich, M. Detmar
semanticscholar   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread

Science Advances, 2018
Lymphatic vessels promote organ-to-organ metastasis in addition to mediating tumor cell dissemination from the primary site. Tumor lymphangiogenesis is accompanied by a higher incidence of sentinel lymph node metastasis and shorter overall survival in ...
Qiaoli Ma, L. Dieterich, K. Ikenberg, Samia B. Bachmann, J. Mangana, Steven T. Proulx, V. Amann, M. Levesque, R. Dummer, P. Baluk, D. McDonald, M. Detmar   +11 more
semanticscholar   +1 more source