Results 31 to 40 of about 147,823 (327)
Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function
Frontiers in Cell and Developmental Biology, 2023 Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. We and others recently reported that somatic activating mutations in KRAS can cause CLAs.
Lorenzo M. Fernandes +7 more
doaj +1 more source
The intestinal lymphatic system: Functions and metabolic implications [PDF]
, 2019 The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well as in immunosurveillance and removal of interstitial fluid.
Cifarelli, Vincenza, Eichmann, Anne
core +2 more sources
Chronic high-fat diet impairs collecting lymphatic vessel function in mice.
PLoS ONE, 2014 Lymphatic vessels play an essential role in intestinal lipid uptake, and impairment of lymphatic vessel function leads to enhanced adipose tissue accumulation in patients with lymphedema and in genetic mouse models of lymphatic dysfunction.
Katrin S Blum +7 more
doaj +1 more source
High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma [PDF]
, 2016 Tongue cancer has a poor prognosis due to its early metastasis via lymphatic vessels. The present study aimed at evaluating lymphatic vessel density, relative density of lymphatic vessel, and diameter of lymphatic vessels and its predictive role in ...
Huhtala, Heini +8 more
core +1 more source
F1000Research, 2019 The heart contains a complex network of blood and lymphatic vessels. The coronary blood vessels provide the cardiac tissue with oxygen and nutrients and have been the major focus of research for the past few decades.
Xiaolei Liu, Guillermo Oliver
doaj +1 more source
Endothelial-specific depletion of TGF-β signaling affects lymphatic function
Inflammation and Regeneration, 2021 Background Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis.
Kunpei Fukasawa +7 more
doaj +1 more source
Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. [PDF]
PLoS ONE, 2013 Vascular endothelial growth factor receptor 2 (VEGFR2) is highly expressed by lymphatic endothelial cells and has been shown to stimulate lymphangiogenesis in adult mice. However, the role VEGFR2 serves in the development of the lymphatic vascular system
Michael T Dellinger +4 more
doaj +1 more source
Frontiers in Physiology, 2023 The lymphatic vasculature provides an essential route to drain fluid, macromolecules, and immune cells from the interstitium as lymph, returning it to the bloodstream where the thoracic duct meets the subclavian vein.
Amanda M. Peluzzo +4 more
doaj +1 more source
Lymphatic Vasculature in Energy Homeostasis and Obesity
Frontiers in Physiology, 2020 Obesity is a leading cause of cardiovascular diseases and cancer. Body mass is regulated by the balance between energy uptake and energy expenditure. The etiology of obesity is determined by multiple factors including genetics, nutrient absorption, and ...
Yen-Chun Ho +2 more
doaj +1 more source
Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors [PDF]
, 2005 The study of lymphatic vessels and lymphatic tumors has been hampered with difficulty due to the overlapping morphological features between blood and lymphatic endothelial cells, as well as to the lack of specific lymphatic endothelial markers.
Adhemar Longatto Filho +36 more
core +1 more source