Results 21 to 30 of about 431,164 (300)

Lymphatic vessels in health and disease [PDF]

WIREs Systems Biology and Medicine, 2012
AbstractThe lymphatic vasculature plays vital roles in tissue fluid balance, immune defense, metabolism, and cancer metastasis. In adults, lymphatic vessel formation and remodeling occur primarily during inflammation, development of the corpus luteum, wound healing, and tumor growth.
Cristina T, Kesler, Shan, Liao, Lance L, Munn, Timothy P, Padera   +3 more
openaire   +2 more sources

Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function

Frontiers in Cell and Developmental Biology, 2023
Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. We and others recently reported that somatic activating mutations in KRAS can cause CLAs.
Lorenzo M. Fernandes, Jeffrey Tresemer, Jing Zhang, Jonathan J. Rios, Jonathan J. Rios, Joshua P. Scallan, Michael T. Dellinger, Michael T. Dellinger   +7 more
doaj   +1 more source

Watching lymphatic vessels grow by making them glow [PDF]

, 2011
A novel imaging technique for visualizing the growth of lymphatic vessels in the cornea is summarized.
Proulx, Steven T, Steven T Proulx, Detmar, Michael, Michael Detmar   +3 more
core   +1 more source

Lymphatic Vessels at the Heart of the Matter [PDF]

Cell Metabolism, 2015
Emergent research in the past decades has brought to light the importance of lymphatic vessels in tissue homeostasis, immunity, metabolism, and inflammation. In Nature, Klotz et al. (2015) demonstrate that cardiac lymphatics have a unique ontology compared to visceral lymphatics and that promoting their growth can improve cardiac function following ...
Angeli, Veronique, Harvey, Natasha L.
openaire   +2 more sources

Morphometric changes in the blood and lymphatic channels during inflammation [PDF]

BIO Web of Conferences
When the abdominal cavity is inflamed, the lymphatic channel, i.e. the system of lymph vessels and lymph nodes, which play an important role in protecting the body from infections and ensuring proper metabolism, may be affected.
Abreshov Serik, Yessenova Makpal, Yeshmukhanbet Anar, Atanbaeva Gulshat, Demchenko Georgiy   +4 more
doaj   +1 more source

Renal lymphatic vessel dynamics

American Journal of Physiology-Renal Physiology, 2020
Similar to other organs, renal lymphatics remove excess fluid, solutes, and macromolecules from the renal interstitium. Given the kidney’s unique role in maintaining body fluid homeostasis, renal lymphatics may be critical in this process. However, little is known regarding the pathways involved in renal lymphatic vessel function, and there are no ...
Elaine L. Shelton, Hai-Chun Yang, Jianyong Zhong, Michele M. Salzman, Valentina Kon   +4 more
openaire   +3 more sources

Chronic high-fat diet impairs collecting lymphatic vessel function in mice.

PLoS ONE, 2014
Lymphatic vessels play an essential role in intestinal lipid uptake, and impairment of lymphatic vessel function leads to enhanced adipose tissue accumulation in patients with lymphedema and in genetic mouse models of lymphatic dysfunction.
Katrin S Blum, Sinem Karaman, Steven T Proulx, Alexandra M Ochsenbein, Paola Luciani, Jean-Christophe Leroux, Christian Wolfrum, Michael Detmar   +7 more
doaj   +1 more source

Endothelial-specific depletion of TGF-β signaling affects lymphatic function

Inflammation and Regeneration, 2021
Background Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis.
Kunpei Fukasawa, Kako Hanada, Kei Ichikawa, Masanori Hirashima, Takahiro Takagi, Susumu Itoh, Testuro Watabe, Fumiko Itoh   +7 more
doaj   +1 more source

Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation

Frontiers in Physiology, 2022
The lymphatic system is crucial for the maintenance of interstitial fluid and protein homeostasis. It has important roles in collecting excess plasma and interstitial fluid leaked from blood vessels, lipid absorption and transportation in the digestive ...
Naoto Ujiie, Tsutomu Kume
doaj   +1 more source

Blood and Lymphatic Vessel Formation [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
Blood and lymphatic vessels deliver oxygen and nutrients, remove waste and CO2, and regulate interstitial pressure in tissues and organs. These vessels begin life early in embryogenesis using transcription factors and signaling pathways that regulate differentiation, morphogenesis, and proliferation.
Victoria L, Bautch, Kathleen M, Caron
openaire   +2 more sources