Prox1 Is a Marker for AII Amacrine Cells in the Mouse Retina
Frontiers in Neuroanatomy, 2017 The transcription factor Prox1 is expressed in multiple cells in the retina during eye development. This study has focused on neuronal Prox1 expression in the inner nuclear layer (INL) of the adult mouse retina.
Nicholas C Brecha +2 more
exaly +3 more sources
The Role of PROX1 in Neoplasia: A Key Player Often Overlooked
Diagnostics, 2022 The human PROX1 gene (Prospero homeobox gene 1) is a member of the homeobox transcription factor family. PROX1 plays a key role in the development of the lymphatic system and is primarily used as a lymphatic vessel marker.
Stamatios Theocharis +2 more
exaly +3 more sources
NDUFS1 promotes malignant breast cancer behaviors through enhancement of mitochondrial respiration and PROX1/c-Myc signaling [PDF]
iScienceSummary: Cancer cells exploit oxidative phosphorylation (OXPHOS) for growth and metastasis. NDUFS1, the largest subunit of the electron transport chain complex I, is a promising therapeutic target in cancer but has a context-dependent role.
Yen-Yun Wang +10 more
doaj +2 more sources
PROX1-associated lymphatic reprogramming signatures in pediatric adamantinomatous craniopharyngioma: a comparative study with adult cases [PDF]
Frontiers in PediatricsBackgroundAdamantinomatous craniopharyngioma (ACP) is the most common sellar tumor in children. Although histologically benign, pediatric ACP often exhibits marked local invasiveness and a high postoperative recurrence rate.
Wanyu Zhang +3 more
doaj +2 more sources
Impaired lymphatic drainage in a child with hydrops fetalis and a novel variant in the PROX1 gene: case report and review of literature [PDF]
Frontiers in Cardiovascular MedicinePROX1 is a gene that encodes a protein that may play a key role in the development of the lymphatic system. This report describes impaired lymphatic drainage, with non-immune hydrops fetalis, congenital bilateral chylothorax, chylous ascites, and the ...
Domenico Umberto De Rose +16 more
doaj +2 more sources
Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system [PDF]
JCI InsightThe central nervous system (CNS) parenchyma has conventionally been believed to lack lymphatic vasculature, likely owing to a non-permissive microenvironment that hinders the formation and growth of lymphatic endothelial cells (LECs).
Sara González-Hernández +9 more
doaj +2 more sources
Prox1 Is Linked to Metastasis and Poor Prognosis by Promoting Lymphangiogenesis in Melanoma [PDF]
Clinical, Cosmetic and Investigational DermatologyChen Cao,1,* Wei Ju,2,* Ling-Qiao Li,1 De-Ming Li,2 Wei Zhang,2 Xi-Hu Yang,3 Zhi-Xin Yan4 1Department of Burn and Plastic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, People’s Republic of ...
Cao C +6 more
doaj +2 more sources
Prox1 and FOXC2 act as regulators of lymphangiogenesis and angiogenesis in oral squamous cell carcinoma. [PDF]
PLoS ONE, 2014 Prospero homeobox 1 (Prox1) and forkhead box (FOX) C2 regulate angiogenesis and/or lymphangiogenesis. However, the detailed role and function of Prox1 and FOXC2 in cancer remains controversial.
Tomonori Sasahira +7 more
doaj +1 more source
Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development
Gastro Hep Advances, 2022 Background and Aims: An interactive regulatory network assembled through the induction and downregulation of distinct transcription factors governs acinar cell maturation.
Angelica S. Martinez-Ramirez +7 more
doaj +1 more source
Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. [PDF]
PLoS ONE, 2013 Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the first and rate-limiting step in the classical pathway of bile acids synthesis in liver and is crucial for maintaining lipid homeostasis.
Huafang Ouyang +4 more
doaj +1 more source