The Role of PROX1 in Neoplasia: A Key Player Often Overlooked
Diagnostics, 2022 The human PROX1 gene (Prospero homeobox gene 1) is a member of the homeobox transcription factor family. PROX1 plays a key role in the development of the lymphatic system and is primarily used as a lymphatic vessel marker.
Stamatios Theocharis +2 more
exaly +3 more sources
Impaired lymphatic drainage in a child with hydrops fetalis and a novel variant in the PROX1 gene: case report and review of literature [PDF]
Frontiers in Cardiovascular MedicinePROX1 is a gene that encodes a protein that may play a key role in the development of the lymphatic system. This report describes impaired lymphatic drainage, with non-immune hydrops fetalis, congenital bilateral chylothorax, chylous ascites, and the ...
Domenico Umberto De Rose +16 more
doaj +2 more sources
Lymphatic Endothelial Cells in Health and Disease. [PDF]
MedComm (2020)Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Tang D +5 more
europepmc +2 more sources
Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system [PDF]
JCI InsightThe central nervous system (CNS) parenchyma has conventionally been believed to lack lymphatic vasculature, likely owing to a non-permissive microenvironment that hinders the formation and growth of lymphatic endothelial cells (LECs).
Sara González-Hernández +9 more
doaj +2 more sources
Two rare PROX1 variants in patients with lymphedema
Molecular Genetics & Genomic Medicine, 2020 Background The PROX1 gene is specifically expressed in a subpopulation of endothelial cells that, by budding and sprouting, give rise to the lymphatic system.
Pietro Chiurazzi +1 more
exaly +2 more sources
Prox1 Is Linked to Metastasis and Poor Prognosis by Promoting Lymphangiogenesis in Melanoma [PDF]
Clinical, Cosmetic and Investigational DermatologyChen Cao,1,* Wei Ju,2,* Ling-Qiao Li,1 De-Ming Li,2 Wei Zhang,2 Xi-Hu Yang,3 Zhi-Xin Yan4 1Department of Burn and Plastic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, People’s Republic of ...
Cao C +6 more
doaj +2 more sources
Prox1 and FOXC2 act as regulators of lymphangiogenesis and angiogenesis in oral squamous cell carcinoma. [PDF]
PLoS ONE, 2014 Prospero homeobox 1 (Prox1) and forkhead box (FOX) C2 regulate angiogenesis and/or lymphangiogenesis. However, the detailed role and function of Prox1 and FOXC2 in cancer remains controversial.
Tomonori Sasahira +7 more
doaj +1 more source
Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development
Gastro Hep Advances, 2022 Background and Aims: An interactive regulatory network assembled through the induction and downregulation of distinct transcription factors governs acinar cell maturation.
Angelica S. Martinez-Ramirez +7 more
doaj +1 more source
Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. [PDF]
PLoS ONE, 2013 Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the first and rate-limiting step in the classical pathway of bile acids synthesis in liver and is crucial for maintaining lipid homeostasis.
Huafang Ouyang +4 more
doaj +1 more source
Cells, 2023 Breast cancer is one of the most lethal malignancies in women worldwide and is characterized by rapid growth and low survival rates, despite advances in tumor biology and therapies.
Artemis Michail +4 more
doaj +1 more source