Results 31 to 40 of about 9,468 (203)
Cells, 2022 The MTOR signal is known to be activated in various cancer cells including hepatocellular carcinoma (HCC) cells. Rapamycin, a specific inhibitor of MTOR, has been widely used as an immunosuppressant in organ transplant patients, and its clinical ...
Sora Kwon +4 more
doaj +1 more source
PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnthigh Metastatic Colon Cancer Cells
Cell Reports, 2014 The Wnt pathway is abnormally activated in the majority of colorectal cancers, and significant knowledge has been gained in understanding its role in tumor initiation.
Simone Ragusa +17 more
doaj +1 more source
Genetic and Molecular Insights Into the Role of PROX1 in Glucose Metabolism [PDF]
Diabetes, 2013 Genome-wide association studies have shown that the rs340874 single nucleotide polymorphism (SNP) in PROX1 is a genetic susceptibility factor for type 2 diabetes. We conducted genetic and molecular studies to better understand the role of PROX1 in type 2 diabetes. We assessed the impact of the whole common genetic variability of PROX1 (80 SNPs) on type
Lecompte, Sophie +12 more
openaire +2 more sources
Prox1 Function Is Required for the Development of the Murine Lymphatic System [PDF]
Cell, 1999 The lack of specific markers has raised problems in documenting the precise manner by which the lymphatic system develops. Here we report that the homeobox gene Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system.
Wigle, Jeffrey T, Oliver, Guillermo
openaire +2 more sources
Loss of Function of the Candidate Tumor Suppressor prox1 by RNA Mutation in Human Cancer Cells
Neoplasia: An International Journal for Oncology Research, 2006 The importance of genetic mutations in carcinogenesis has been recognized, and it has been proposed that aberrant mutation of mRNA may represent a novel oncogenic principle.
Meiko Takahashi +9 more
doaj +1 more source
Expression of prospero-related homeobox protein 1 and its significance in non-small cell lung cancer
Zhongguo aizheng zazhi, 2020 Background and purpose: Prospero-related homeobox protein 1 (PROX1) is a highly conserved transcription regulator, which is involved in the occurrence and development of many types of tumors. The purpose of this study was to investigate the expression of
YANG Guang, ZHANG Kun, WANG Jun
doaj
PROX1 upregulates HEY1 in primary LECs.
, 2012 (A) Knockdown of PROX1, but not COUP-TFII, resulted in downregulation of HEY1 in LECs. qRT-PCR analyses were performed to determine the expression of HEY1, PROX1 and COUP-TFII in primary LECs that were transfected for 48 hours with siRNAs targeting the ...
Young-Kwon Hong (158165) +14 more
core +1 more source
Comparison of the Prox1-Cre-tdTomato mouse with the Prox1-Cre-tdRFP mouse.
, 2015 A Intravital confocal microscopy revealed brighter lymphatic vessels in the Prox1-Cre-tdTomato mouse than in the Prox1-Cre-tdRFP mouse (images acquired applying the same laser power and settings).
René Hägerling (717805) +9 more
core +1 more source
Charting Endocrine Progenitors Across Species and Organs
Advanced Science, EarlyView.Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing +21 more
wiley +1 more source
PROX1 protein expression in RCC cells and the effect of PROX1 on cell proliferation.
, 2014 (a) PROX1 expression in wild-type RCC cells (786-O, 769-P, OS-RC-2, and ACHN) and human renal proximal tubular epithelial cells (HKC). (b) PROX1 expression in RCC cells infected with lentiviruses.
Youhua Xie (405867) +9 more
core +1 more source