Results 41 to 50 of about 9,468 (203)
The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation [PDF]
, 2016 The remarkable adaptive and regenerative capacity of skeletal muscle is regulated by several transcription factors and pathways. Here we show that the transcription factor Prox1 is an important regulator of myoblast differentiation and of slow muscle ...
Salmela, I. +13 more
core +1 more source
Fasting‐sensitive SUMO‐switch on Prox1 controls hepatic cholesterol metabolism
, 2023 Accumulation of excess nutrients hampers proper liver function and is linked to nonalcoholic fatty liver disease (NAFLD) in obesity. However, the signals responsible for an impaired adaptation of hepatocytes to obesogenic dietary cues remain still ...
Mhamane, Amit +10 more
core +1 more source
Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter [PDF]
Nucleic Acids Research, 2001 Gamma-crystallin genes are specifically expressed in the eye lens. Their promoters constitute excellent models to analyse tissue-specific gene expression. We investigated murine CRYGE/f promoters of different length in lens epithelial cell lines. The most active fragment extends from position -219 to +37.
Lengler, Johannes +5 more
openaire +3 more sources
Advanced Science, EarlyView.Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu +8 more
wiley +1 more source
PLoS ONE, 2015 Central nervous system injury induces a regenerative response in ensheathing glial cells comprising cell proliferation, spontaneous axonal remyelination, and limited functional recovery, but the molecular mechanisms are not fully understood.
Kentaro Kato +5 more
doaj +1 more source
Comprehensive Analysis of Porcine Prox1 Gene and Its Relationship with Meat Quality Traits
Animals, 2019 Prox1 is involved in muscle fiber conversion, adult-onset obesity, and type 2 diabetes. However, information regarding porcine Prox1 and its relationship with meat quality traits is still unknown.
Chao Dong +9 more
doaj +1 more source
Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction
Advanced Science, EarlyView.In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng +12 more
wiley +1 more source
Prox1 expression in the developing mouse kidney.
, 2015 Double immunofluorescence staining for CLC-K1 (A, green) and Prox1 (B, red), NKCC2 (D, green) and Prox1 (E, red), AQP1 (G, green) and Prox1 (H, red), AQP2 (J, green) and Prox1 (K, red), and CD31 (M, green) and Prox1 (N, red) in renal papilla of 4-day-old
Yu-mi Kim (741298) +7 more
core +1 more source
IBRO Neuroscience ReportsBackground: Peripheral nerve injury (PNI), such as sciatic nerve injury (SNI), often results in poor functional recovery due to myelin damage, which critically impairs nerve regeneration.
Linlin Jie +6 more
doaj +1 more source
PLoS ONE, 2010 BackgroundThe homeobox gene Prox1 is required for lens, retina, pancreas, liver, and lymphatic vasculature development and is expressed in inner ear supporting cells and neurons.Methodology/principal findingsWe have investigated the role of Prox1 in the ...
Bernd Fritzsch +4 more
doaj +1 more source