Results 61 to 70 of about 9,468 (203)

PROX1: a lineage tracer for cortical interneurons originating in the lateral/caudal ganglionic eminence and preoptic area.

PLoS ONE, 2013
The homeobox-encoding gene Prox1 and its Drosophila homologue prospero are key regulators of cell fate-specification. In the developing rodent cortex a sparse population of cells thought to correspond to late-generated cortical pyramidal neuron ...
Anna Noren Rubin, Nicoletta Kessaris
doaj   +1 more source

Protein O‐Glycosylation Shapes Lymphatic Endothelia and Lymph Node Macrophage Populations

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
To study the functional roles of O‐glycans on lymphatic endothelia, we deleted Cosmc, the chaperone required for core‐1 O‐glycan synthesis. Loss of core‐1 O‐glycans entailed major changes in glycoprotein composition of lymphatic endothelial cells (LEC), including reduced podoplanin (Pdpn), CD44, and Lyve‐1, and increased ICAM‐1; reduced CD44 was caused
Jasmin Frey, Annkathrin Ratter, Finn Brigger, Louie Cielen, Pascal Kunz, Ea Tulin, Kinga Mikos, Lothar Dieterich, Marco D'Addio, Cornelia Halin, Richard D. Cummings, Vivianne I. Otto   +11 more
wiley   +1 more source

Prox1 function in the OL cell lineage.

, 2016
(A) Comparison of Drosophila enwrapping interface glia (IG) and mammalian OPCs and OLs. Drosophila glia are differentiated cells that enwrap axons, recycle neurotransmitters, proliferate upon injury and express both Notch and pros. OPCs are proliferative
Daijiro Konno (131214), Martin Berry (9359), Fumio Matsuzaki (131236), Kentaro Kato (35147), Ann Logan (9361), Alicia Hidalgo (208713)   +5 more
core   +1 more source

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source

Expression of Prox1 in postnatal PANs.

, 2017
Cochlear cross sections of postnatal SG at P1 (A, B), P6 (C), P14 (D, D’) and P30 (E). A: At P1, Prox1 (green) was positive in TuJ1 (white) positive PANs in SG and the supporting cells in the organ of Corti. B: High magnification image of SG in A, except
Teppei Noda (848954), Koji Nishimura (2077804), Alain Dabdoub (848958)   +2 more
core   +1 more source

Podoplanin and PROX1 Expression in Hypercaloric Diet-induced Pancreatic Injuries [PDF]

In Vivo, 2019
The role of podoplanin (PDPN) and homebox prospero gene 1 (PROX1) in early stages of pancreatic islet changes induced by hypercaloric diet is unclear. The aim of this study was to study PDPN and PROX1 variability in pancreatic islets after a hypercaloric diet in a rat experimental model.Pancreatic biopsies harvested from Sprague-Dawley rats at 3, 6 ...
Delia, Taran, Valeria Nicoleta, Tarlui, Raluca Amalia, Ceausu, Anca Maria, Cimpean, Marius, Raica, Simona, Sarb   +5 more
openaire   +2 more sources

The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei

Developmental Dynamics, Volume 255, Issue 9, Page 845-866, September 2026.
Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Jeong Han Lee, Ebenezer N. Yamoah, Jennifer Kersigo, Karen Elliott, Niya LaRoda, Gabriela Pavlinkova, Bernd Fritzsch   +6 more
wiley   +1 more source

Characterization of the mouse Prox1 gene.

, 1998
Prox1, a vertebrate homologue of Drosophila prospero, encodes a divergent homeodomain protein. We have isolated and characterized full length mouse Prox1 cDNA and genomic clones.
Chang, B, Hawes, N L, Zinovieva, R D, Tomarev, S I   +3 more
core   +1 more source

Beyond the Classics: The Synergy of AI and Genomics Reveals an Expanded Repertoire of Pigmentation Genes

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 346, Issue 6, Page 475-486, September 2026.
Classical approaches for coloration analysis are limited by human low‐resolution phenotyping and genetic analysis. Artificial intelligence allows us to find genes beyond the tip of the iceberg that explain color and pattern diversity in nature. ABSTRACT Pigmentation has long served as a powerful system for exploring gene–trait relationships, yet much ...
Ehsan Pashay Ahi, Nidal Karagic
wiley   +1 more source

lncRNA PROX1-AS1负调控miR-206对鼻咽癌细胞SUNE1增殖、迁移侵袭的影响

Zhongguo shiyan zhenduanxue, 2021
目的探讨长链非编码RNA(lncRNA)PROX1反义RNA1(PROX1-AS1)是否靶向miR-206影响鼻咽癌细胞SUNE1的增殖、迁移和侵袭。方法采用实时定量PCR(RT-qPCR)检测鼻咽癌组织和癌旁组织中PROX1-AS1和miR-206表达。双荧光素酶报告实验和RT-qPCR分析PROX1-AS1和miR-206靶向关系。细胞计数试剂盒(CCK-8)法、克隆形成实验、Transwell实验检测PROX1-AS1和miR-206表达对SUNE1细胞增殖活力、克隆形成数、迁移和侵袭细胞数的影响。
袁小卫, 王彦君, 熊健, 何学祥
doaj