Results 71 to 80 of about 9,468 (203)

Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish

Cell Reports, 2015
Lymphatic vessels arise chiefly from preexisting embryonic veins. Genetic regulators of lymphatic fate are known, but how dynamic cellular changes contribute during the acquisition of lymphatic identity is not understood.
Katarzyna Koltowska, Anne Karine Lagendijk, Cathy Pichol-Thievend, Johanna C. Fischer, Mathias Francois, Elke A. Ober, Alpha S. Yap, Benjamin M. Hogan   +7 more
doaj   +1 more source

IMMUNOHISTOCHEMICAL STUDY OF PROTEINS PROX1, CD133 AND CD38 IN GLIOBLASTOMAS OF THE VENTRICULARSUBVENTRICULAR ZONE AND THEIR EFFECT ON THE LIFE EXPECTANCY OF PATIENTS

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2020
Introduction. Glioblastoma (GBM) is one of the most malignant tumors. Currently, treatment options for GBM are limited, and patient survival rates over the past decades have not changed significantly.The objective of the study was a comparative study of ...
B. E. Galkovsky, L. B. Mitrofanova, Iu. S. Lakhina, D. A. Gulyaev, V. Y. Chirkin, N. A. Mitrofanov, I. V. Chistova   +6 more
doaj   +1 more source

Novel Therapeutic Insights Into Alzheimer's Disease: Glymphatic System and Meningeal Lymphatic Vessels

Aging Cell, Volume 25, Issue 9, September 2026.
The identification of the glymphatic system (GS) and meningeal lymphatic vessels (mLVs) challenges the century‐old “immune‐privileged” dogma of the central nervous system (CNS), establishing a critical mechanistic link between impaired waste clearance (Aβ/tau) and the pathogenesis of Alzheimer's disease (AD).
Bingbing Song, Wei Wang, Siqi Liu, Xi Jin, Yan Qi, Mingquan Li, Dongjie Yue, Yu Liu, Xiangqi Li, Lei Yin, Lina Feng   +10 more
wiley   +1 more source

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction [PDF]

Nucleic Acids Research, 2016
The transcription factor (TF) SOX18 drives lymphatic vessel development in both embryogenesis and tumour-induced neo-lymphangiogenesis. Genetic disruption of Sox18 in a mouse model protects from tumour metastasis and established the SOX18 protein as a molecular target.
Hou, Linlin, Jauch, Ralf, Klaus, Miriam, Prokoph, Nina, Narasimhan, Kamesh, Francois, Mathias, Srivastava, Yogesh, Huang, Yong Heng, Wang, Xuecong, Girbig, Mathias, Kolatkar, Prasanna R.   +10 more
openaire   +6 more sources

PROX1 Expression in Resected Non-Small Cell Lung Cancer: Immunohistochemical Profile and Clinicopathological Correlates

Medical Sciences
Background/Objectives: PROX1 (prospero homeobox 1) is a transcription factor involved in lymphangiogenesis and cellular differentiation. Its role in cancer biology appears to be highly context-dependent, with it exhibiting both tumor-promoting and ...
Evangelia Ntikoudi, Thomas Karagkounis, Konstantinos S. Mylonas, Stylianos Kykalos, Dimitrios Schizas, Ioannis N. Vamvakaris, Ekaterini Politi, Michail V. Karamouzis, Stamatios Theocharis   +8 more
doaj   +1 more source

Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation

Neoplasia: An International Journal for Oncology Research, 2016
The current paradigm of pancreatic neoplastic transformation proposes an initial step whereby acinar cells convert into acinar-to-ductal metaplasias, followed by progression of these lesions into neoplasias under sustained oncogenic activity and ...
Yiannis Drosos, Geoffrey Neale, Jianming Ye, Leena Paul, Emin Kuliyev, Anirban Maitra, Anna L Means, M Kay Washington, Jerold Rehg, David B Finkelstein, Beatriz Sosa-Pineda   +10 more
doaj   +1 more source

Human iPSC‐Derived Brain Organoids: A Disease‐Oriented Evaluation of Modeling Fidelity

European Journal of Neuroscience, Volume 64, Issue 5, September 2026.
Organoids are self‐organizing 3D structures that mimic organ architecture and function with multiple cell types arranged in spatial patterns. Brain organoids can be patterned towards specific regions and can incorporate glial and microglial components.
Bishwa R. Pokharel, Abigail Dickerson, Sanjana G. Shenoy, Mira S. Ramasamy, Niska Majumdar, Paul P. Cook, Shaw M. Akula   +6 more
wiley   +1 more source

PROX1 expression in the embryonic forebrain.

, 2013
(A–D) Immunolabeling for PROX1 in coronal sections of the forebrain at E12.5 and E14.5. Expression can be seen in the SVZ of the MGE, dorsal LGE (dLGE), CGE and POA as well as in the dentate neuroepithelium (DNE), thalamus (Thal) and hypothalamus (Hyp). (
Anna Noren Rubin (470529), Nicoletta Kessaris (223097)   +1 more
core   +1 more source

PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma [PDF]

BMC Cancer, 2016
The Wnt/β-catenin pathway has a key role in regulating cellular processes and its aberrant signaling can lead to cancer development. The role of β-catenin expression in pancreatic ductal adenocarcinoma is somewhat controversial. Transcription factor PROX1 is a target of Wnt/β-catenin signaling and it is involved in carcinogenesis through alterations in
Saukkonen, Kapo, Hagström, Jaana, Mustonen, Harri, Juuti, Anne, Nordling, Stig, Kallio, Pauliina, Alitalo, Kari, Seppänen, Hanna, Haglund, Caj   +8 more
openaire   +2 more sources

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, Volume 13, Issue 47, 24 August 2026.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source