Results 91 to 100 of about 9,468 (203)
STAT5a/b proteins bind to the PROX1 proximal promoter and mediate IL3Rα-induced PROX1 upregulation.
, 2012 (A) Adenoviral overexpression of IL3Rα increased phosphorylation of STAT5a/b (p-STAT5a/b) in BECs and HUVECs, but not LECs. AdCTR, control adenovirus; AdIL3Rα, IL3Rα-expressing adenovirus.
Young-Kwon Hong (158165) +14 more
core +1 more source
Prox1 expression in the cochlea is biphasic.
, 2013 A. As shown by X-gal staining, at E13.5 Prox1 expression in the cochlea is higher in the apex and gradually faints toward the base; with limited expression in delaminating sensory neurons (SPG in A, A′). B,C.
Miriam Dillard (366841) +4 more
core +1 more source
Hair cell differentiation is not required for Prox1 expression.
, 2013 A, B. Prox1 expression is maintained in undifferentiated supporting cells of E18.5 Atoh1- null embryos. This result argues that Prox1 expression is independent of hair cell mediated differentiation of sensory epithelia.
Miriam Dillard (366841) +4 more
core +1 more source
Cell Reports, 2014 Colorectal cancer (CRC) initiation and growth is often attributed to stem cells, yet little is known about the regulation of these cells. We show here that a subpopulation of Prox1-transcription-factor-expressing cells have stem cell activity in ...
Zoltán Wiener +11 more
doaj +1 more source
Role of transcription factor PROX1 in colon cancer metastasis
, 2013 Initiation and progression of most colorectal cancers (CRCs) are driven by hyper-activation of the canonical Wnt/ß-catenin/TCF signaling pathway. However, a basal level of activation of this pathway is necessary for intestinal cell homeostasis; thus only
Ragusa, S.
core +1 more source
PLoS Biology, 2010 The dentate gyrus has an important role in learning and memory, and adult neurogenesis in the subgranular zone of the dentate gyrus may play a role in the acquisition of new memories.
Alfonso Lavado +4 more
doaj +1 more source
Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression. [PDF]
Cancer ResAbstract Histologic transformation of prostate cancer from adenocarcinoma to neuroendocrine prostate cancer (NEPC) is associated with aggressive disease and poor prognosis. This lineage transition is accompanied by polycomb complex 2–mediated epigenetic derepression of cell fate–determining ...
Venkadakrishnan VB +9 more
europepmc +4 more sources
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Frontiers in PediatricsBackgroundAdamantinomatous craniopharyngioma (ACP) is the most common sellar tumor in children. Although histologically benign, pediatric ACP often exhibits marked local invasiveness and a high postoperative recurrence rate.
Wanyu Zhang +3 more
doaj +1 more source
Zhongguo aizheng zazhi, 2019 Background and purpose: Prospero-related homeobox 1 (PROX1), a member of the homeodomain transcription factor family, is involved in the development and progression of a variety of malignant tumors, and is closely related to tumor cell proliferation ...
赵东丽 +3 more
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