PROX1 is a transcriptional regulator of MMP14 [PDF]
Scientific Reports, 2018 The transcription factor PROX1 is essential for development and cell fate specification. Its function in cancer is context-dependent since PROX1 has been shown to play both oncogenic and tumour suppressive roles.
Silvia Gramolelli +15 more
doaj +10 more sources
Altered regulation of Prox1-gene-expression in liver tumors [PDF]
BMC Cancer, 2008 Background Prospero-related homeobox 1 (Prox1) transcription factor was described as a tumor-suppressor gene in liver tumors. In contrast, Prox1 knock out in murine embryos drastically reduces proliferation of hepatoblasts.
Füzesi Laszlo +7 more
doaj +6 more sources
High PROX1 expression in gastric cancer predicts better survival. [PDF]
PLoS ONE, 2017 PROX1 is a transcription factor involved in the development of various organs. It has also an important function in colorectal cancer progression. The aim of this study was to investigate the prognostic role of PROX1 expression in gastric cancer.We ...
Alli Laitinen +5 more
doaj +7 more sources
Prox1 regulates the notch1-mediated inhibition of neurogenesis. [PDF]
PLoS Biology, 2010 Activation of Notch1 signaling in neural progenitor cells (NPCs) induces self-renewal and inhibits neurogenesis. Upon neuronal differentiation, NPCs overcome this inhibition, express proneural genes to induce Notch ligands, and activate Notch1 in ...
Valeria Kaltezioti +8 more
doaj +7 more sources
Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. [PDF]
PLoS Pathogens, 2010 Kaposi's sarcoma (KS) is the most common cancer among HIV-positive patients. Histogenetic origin of KS has long been elusive due to a mixed expression of both blood and lymphatic endothelial markers in KS tumor cells.
Jaehyuk Yoo +11 more
doaj +2 more sources
Prox1 Is a Marker for AII Amacrine Cells in the Mouse Retina [PDF]
Frontiers in Neuroanatomy, 2017 The transcription factor Prox1 is expressed in multiple cells in the retina during eye development. This study has focused on neuronal Prox1 expression in the inner nuclear layer (INL) of the adult mouse retina.
Luis Pérez de Sevilla Müller +6 more
doaj +3 more sources
Impact of an altered PROX1 expression on clinicopathology, prognosis and progression in renal cell carcinoma. [PDF]
PLoS ONE, 2014 The transcription factor PROX1 (prospero homeobox 1) has a critical role in the development of various organs, and has been implicated in both oncogenic and tumor-suppressive functions in human cancers.
Tao Lv +9 more
doaj +2 more sources
PROX1 is an early driver of lineage plasticity in prostate cancer
The Journal of Clinical InvestigationLineage plasticity is recognized as a critical determinant of lethality and resistance to AR pathway inhibitors in prostate cancer. Lineage plasticity is a continuum, ranging from AR activity-low tumors, AR-null tumors that do not express a ...
Zhi Duan +45 more
doaj +3 more sources
A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research. [PDF]
PLoS ONE, 2015 The lymphatic vascular system plays an active role in immune cell trafficking, inflammation and cancer spread. In order to provide an in vivo tool to improve our understanding of lymphatic vessel function in physiological and pathological conditions, we ...
Roberta Bianchi +9 more
doaj +3 more sources
Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice [PDF]
, 2016 Prox1 heterozygous mice have a defective lymphatic vasculature and develop late-onset obesity. Chyle abnormally leaks from those vessels, accumulates in the surrounding tissues, and causes an increase in adipose tissue. We characterized the lymphatics of
Steven T. Proulx +13 more
core +2 more sources