Results 171 to 180 of about 109,722 (264)

Cutaneous Hematologic Neoplasms in Children: Overview and Update. [PDF]

Dermatopathology (Basel)
Drabent P, Welfringer A, Gru AA, Molina TJ, Fraitag S.   +4 more
europepmc   +1 more source

Human APOBEC3G suppresses homologous recombination and LIG4‐independent end joining in DNA double‐strand break repair

The FEBS Journal, EarlyView.
Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito, Miori Murayama, Usaki Arai, Sekifumi Akatsu, Ami Yamamoto, Misaki Kadoguchi, Noritaka Adachi   +6 more
wiley   +1 more source

Clinico-Hematological and Immunophenotypic Profile of Leukemia Patients at a Tertiary Care Center in Jharkhand, India: A Cross-Sectional Study. [PDF]

Cureus
Shome A, Paswan MK, Jamaiyar A, Shome A.
europepmc   +1 more source

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

Central nervous system penetration of imatinib in acute lymphoblastic leukemia: Pharmacokinetic analysis and clinical implications. [PDF]

Cancer Chemother Pharmacol
Rasmussen ASB, Rank CU, Christensen IJ, Weimann A, Hansen K, Thastrup M, Yang T, Lund TM, Wik HS, Vogt H, Norén-Nyström U, Vaitkeviciene G, Albertsen BK, Wehner PS, Als-Nielsen B, Andersen CL, Dalhoff K, Schmiegelow K.   +17 more
europepmc   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Exploring the role of blinatumomab in pediatric B-lymphoblastic lymphoma (B-LLy). [PDF]

Blood Adv
Devine KJ, Fries C, Wistinghausen B.
europepmc   +1 more source

Clonal Hematopoiesis and CAR T Cell Therapy: From Biological Crosstalk to Clinical Implications

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Clonal hematopoiesis (CH) is increasingly recognized as a significant biological phenomenon in aging and cancer, marked by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations in genes associated with myeloid neoplasms.
Wei Du, Shunsuke Koga, Guang Yang, Saar Gill, Adam Bagg   +4 more
wiley   +1 more source

<i>CEBP</i> and <i>ZEB2</i> alterations define three distinct subtypes of B-cell acute lymphoblastic leukemia. [PDF]

Hemasphere
Kim R, Passet M, Bergugnat H, Vasseur L, Leguay T, Huguet F, Hunault M, Sexton T, Benlebna M, Renard J, Raffoux E, Pastoret C, Erb C, Chat L, Delabesse E, Gachet S, Bonmati C, Balsat M, Braun T, Bidet A, Duployez N, Graux C, Chalandon Y, Rousselot P, Chevallier P, Soulier J, Lhéritier V, Dombret H, Boissel N, Clappier E.   +29 more
europepmc   +1 more source

Management of Non‐Plaque‐Induced Gingival Conditions: A Systematic Review—Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims This systematic review assesses current evidence on the management of non‐plaque (dental biofilm)‐induced gingival diseases and conditions (NPIGDs), including (i) inflammatory and immune conditions, (ii) neoplasms and (iii) gingival pigmentations.
Maria Clotilde Carra, Cecile Wasielewski, Bruno Špiljak, Maja Sabalić‐Schoener, Sebastien Jungo, Ivan Alajbeg   +5 more
wiley   +1 more source