Results 141 to 150 of about 270,921 (246)

Cardiovascular Toxicity Associated With Bispecific Antibodies in Hematological Malignancies: A Comprehensive Pharmacovigilance Analysis

American Journal of Hematology, Volume 101, Issue 10, Page 2546-2556, October 2026.
ABSTRACT Cardiovascular adverse events (CVAEs) associated with bispecific T‐cell engaging antibodies (BsAbs) have not been systematically investigated across approved agents. In this disproportionality analysis of FAERS (December 2014–September 2025), reports listing BsAbs as the primary suspected drug (n = 7647) were compared with all other drugs in ...
Malak Munir, Ahmed Sayed, Dae Hyun Lee, Sanam Ghazi, Mustafa M. Houmsse, Saad Badat, Abdul Moeed, Avirup Guha, Daniel Addison, Narendranath Epperla   +9 more
wiley   +1 more source

Model‐Based Analysis with Mechanistic Insights to CAR‐T‐Cell Therapy Kinetics: Case Study with Axicabtagene Ciloleucel and Brexucabtagene Autoleucel

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1027-1040, October 2026.
Model‐informed drug development is increasingly used to support chimeric antigen receptor (CAR)‐T‐cell therapy programs. However, most population pharmacokinetic (PK) CAR‐T‐cell models available in literature are variations of an empirical piecewise‐linear model, which accurately describes the observed data but lacks a mechanistic foundation.
Anna M. Mc Laughlin, Martin Bergstrand, Ana Ruiz‐Garcia, Simone Filosto, Rhine Shen   +4 more
wiley   +1 more source

The 9th Edition of the UICC TNM Classification of Malignant Tumours: Updates and Rationale for Change

International Journal of Cancer, Volume 159, Issue 7, Page 1588-1601, 1 October 2026.
ABSTRACT The standard for assessing and recording the extent of the tumour, a necessity for most malignancies, is the Tumour Node Metastases (TNM) classification. The Union for International Cancer Control (UICC) TNM committee has defined this since the early 1950s.
James D. Brierley, Liesbet J. Van Eycken, Meredith E. Giuliani, Brian A. Rous, Shao Hui Huang, Hisao Asamura, Mary K. Gospodarowicz, Anne W. Lee, Brian O'Sullivan   +8 more
wiley   +1 more source

Somatic Mitochondrial–Nuclear DNA Transfer in Lymphoproliferative Disorders

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Introduction Somatic mitochondrial–nuclear DNA transfer (SMNT) is a process by which mitochondrial DNA (mtDNA), of varying sizes, integrate into the nuclear genome and has been previously reported in solid tumours. Methods EuroClonality‐NGS DNA Capture sequencing data from 755 lymphoid malignancies and 59 lymphoid cell lines were analysed for ...
James Peter Stewart, Nikos Darzentas, Miguel Alcoceba, Maria Eugenia Sarasquete, Anthony V. Moorman, Mark Catherwood, Binaya Regmi, Christiane Pott, Anton W. Langerak, David Gonzalez   +9 more
wiley   +1 more source

Clinicopathological features of adult lymphoblastic lymphoma: a retrospective multicenter study from Türkiye. [PDF]

Front Oncol
Selim C, Çiftçiler R, Gören D, Fidan K, Ünal A, Afacan Öztürk HB, Albayrak M, Uluköylü Mengüç M, Atagündüz I, İşleyen E, Özet G, Birtaş Ateşoğlu E.   +11 more
europepmc   +1 more source

An unusual cranial manifestation of B-cell precursor lymphoblastic lymphoma in 10-year-old girl. [PDF]

Childs Nerv Syst
Bardońska D, Skadorwa T, Hutnik Ł.
europepmc   +1 more source

Allogeneic Hematopoietic Stem Cell Transplantation Achieves Durable Remission in Blast‐Phase Chronic Myeloid Leukemia Presenting as Early T‐Cell Precursor Acute Lymphoblastic Leukemia

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Introduction The presentation of chronic myeloid leukemia (CML) in the blast phase as early T‐cell precursor acute lymphoblastic leukemia (ETP‐ALL) is very rare. As previously reported, in contrast to B‐ALL, the prognosis is poor. Case Presentation We encountered a patient with blast phase CML presenting as ETP‐ALL.
Takafumi Tsushima, Yukiko Konishi, Natsumi Yoda, Koichiro Wada, Kento Okamoto, Kosuke Matsuo, Shuntaro Isogai, Sonoko Shimoji, Yoshikazu Utsu, Shin‐Ichi Masuda, Nobuyuki Aotsuka   +10 more
wiley   +1 more source

Primary Mediastinal T-Lymphoblastic Lymphoma With Airway Stenosis Diagnosed Using Endobronchial Ultrasound-Guided Transbronchial Mediastinal Cryobiopsy: A Case Report. [PDF]

Respirol Case Rep
Nagamine H, Bungo M, Nagaki Y, Todoriki A, Niina K, Enomoto K, Kakuno S, Nakai T, Yamada K, Watanabe T, Asai K, Mukai D, Nagasaki J, Nakamae H, Kawaguchi T.   +14 more
europepmc   +1 more source

Advancing In Vivo Chimeric Antigen Receptor T‐Cell Engineering to Accelerate Clinical Translation

MedComm, Volume 7, Issue 10, October 2026.
In vivo CAR‐T cell generation directly engineers endogenous T cells using pre‐manufactured gene delivery vectors that target T cells and deliver CAR‐encoding genetic material. The resulting CAR‐T cells expand in vivo and mediate antigen‐specific cytotoxicity.
Zhenxin Bai, Ming Yi, Shengtao Hu, Dixuan Xue, Luxin Wei, Lifeng Zhang, Zhijun Dai   +6 more
wiley   +1 more source

PIP4K2A depletion suppresses AKT signaling and enhances chemotherapy sensitivity in T-cell lymphoblastic lymphoma cells. [PDF]

Biochem Biophys Res Commun
Chen S, He Z, Ha Y.
europepmc   +1 more source