Results 291 to 300 of about 81,713 (355)

The significance of PAX5 in Merkel cell carcinoma

open access: yesThe Journal of Pathology, Volume 266, Issue 1, Page 81-94, May 2025.
Abstract Merkel cell carcinoma (MCC) is a highly malignant skin cancer that expresses epithelial‐, neuroendocrine‐, and lymphoid‐associated genes. Here, we focused on B‐cell differentiation, which is characterised by the coexpression of PAX5 and TdT. PAX5 is the master regulator of B‐cell commitment and is expressed in 65% of MCC cases.
Emil Chteinberg   +16 more
wiley   +1 more source

Vincristine Sulfate Liposome Injection With Combination Chemotherapy for Children, Adolescents, and Young Adults With Relapsed Acute Lymphoblastic Leukemia: A Therapeutic Advances in Childhood Leukemia and Lymphoma Consortium Trial

open access: yesPediatric Blood &Cancer, Volume 72, Issue 5, May 2025.
ABSTRACT INTRODUCTION Vincristine sulfate liposome injection (VSLI), a liposomal formulation of vincristine, may be better tolerated than standard aqueous vincristine and enable dose intensification. PROCEDURES Based on single‐agent tolerability, activity, and FDA approval in adults with acute lymphoblastic leukemia (ALL), we tested the safety and ...
Nirali N. Shah   +26 more
wiley   +1 more source

Challenges and Opportunities of a Multi‐Institutional Treatment Guideline for Wilms Tumor in Low‐Middle‐Income Countries—A Report From the Asociación de Hemato‐Oncología Pediátrica de Centro América (AHOPCA)

open access: yesPediatric Blood &Cancer, Volume 72, Issue 5, May 2025.
ABSTRACT Since 2000, centers across Central America have shared treatment guidelines for Wilms tumor, using histology (anaplasia present or absent) and tumor stage to stratify patients into low‐, intermediate‐, and high‐risk groups. Weekly virtual tumor board meetings involving local and international experts were held to ensure consistent treatment ...
Patricia Valverde   +15 more
wiley   +1 more source

Higher Rates of Hypersensitivity Reactions to Calaspargase Compared With Pegaspargase: A Single Center Retrospective Review

open access: yesPediatric Blood &Cancer, Volume 72, Issue 5, May 2025.
ABSTRACT Background Asparaginase is a critical component of curative therapy for the treatment of pediatric acute lymphoblastic leukemia (ALL) and acute lymphoblastic lymphoma (LLy). Pegaspargase (PEG) increased the duration of asparagine depletion and lowered the incidence of hypersensitivity reactions (HSRs) compared with native asparaginase.
Kyra McCarty   +7 more
wiley   +1 more source

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