Results 1 to 10 of about 1,723,798 (355)

B cell MHC haplotype affects follicular inclusion, germinal center participation and plasma cell differentiation in a mouse model of lupus

Frontiers in Immunology, 2023
IntroductionMHC class II molecules are essential for appropriate immune responses against pathogens but are also implicated in pathological responses in autoimmune diseases and transplant rejection.
Camilla Wibrand, Thomas R. Wittenborn, Lasse Frank Voss, Lasse Frank Voss, Gudrun Winther, Lisbeth Jensen, Alexey Ferapontov, Alexey Ferapontov, Alexey Ferapontov, Sofie V. Fonager, Cecilia Fahlquist-Hagert, Søren E. Degn, Søren E. Degn   +12 more
doaj   +1 more source

Neutrophil-to-lymphocyte ratio, past, present and future perspectives.

Bratislava Medical Journal, 2021
In the review we analyzed short history of the establishment of a novel hematological parameter for systemic inflammation and stress coined as a neutrophil to lymphocyte ratio (NLR).
R. Záhorec
semanticscholar   +1 more source

Generation of High Quality Memory B Cells

Frontiers in Immunology, 2022
Protection against pathogen re-infection is mediated, in large part, by two humoral cellular compartments, namely, long-lived plasma cells and memory B cells.
Takeshi Inoue, Ryo Shinnakasu, Tomohiro Kurosaki, Tomohiro Kurosaki, Tomohiro Kurosaki   +4 more
doaj   +1 more source

Assessing the impact of an antigen-specific antibody response on atherosclerosis development in mice

STAR Protocols, 2023
Summary: The antibody immune response plays a critical role in atherosclerosis. Here, we present a protocol for assessing the impact of an antigen-specific germinal center antibody response on atherosclerosis development, using a pro-atherogenic mouse ...
Alberto Del Monte-Monge, Inmaculada Martos-Folgado, Ana Rodríguez-Ronchel, Almudena R. Ramiro   +3 more
doaj   +1 more source

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

Science, 2013
Erika L Pearce, Maya Poffenberger, Chih-Hao Chang   +2 more
exaly   +2 more sources

Antigen presentation by B cells enables epitope spreading across an MHC barrier

Nature Communications, 2023
Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE)
Cecilia Fahlquist-Hagert, Thomas R. Wittenborn, Ewa Terczyńska-Dyla, Kristian Savstrup Kastberg, Emily Yang, Alysa Nicole Rallistan, Quinton Raymond Markett, Gudrun Winther, Sofie Fonager, Lasse F. Voss, Mathias K. Pedersen, Nina van Campen, Alexey Ferapontov, Lisbeth Jensen, Jinrong Huang, John D. Nieland, Cees E. van der Poel, Johan Palmfeldt, Michael C. Carroll, Paul J. Utz, Yonglun Luo, Lin Lin, Søren E. Degn   +22 more
doaj   +1 more source

Cell polarity regulators, multifunctional organizers of lymphocyte activation and function

Biomedical Journal, 2022
Cell polarity regulators are ubiquitous, evolutionary conserved multifunctional proteins. They contain a variety of protein–protein interaction domains endowing them the capacity to interact with cytoskeleton structures, membrane components and multiple ...
Marta Mastrogiovanni, Vincenzo Di Bartolo, Andrés Alcover   +2 more
doaj   +1 more source

The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke

Journal of Neuroinflammation, 2021
To investigate the association of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) with post-thrombolysis early neurological outcomes including early neurological improvement (ENI) and early
Pengyu Gong, Yukai Liu, Yachi Gong, Gang Chen, Xiaohao Zhang, Siyu Wang, Feng Zhou, Rui Duan, Wenxiu Chen, Ting Huang, Meng Wang, Q. Deng, Hongchao Shi, Junshan Zhou, Teng Jiang, Yingdong Zhang   +15 more
semanticscholar   +1 more source

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5

Cell Reports, 2020
Summary: The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr)
Ine Vanderleyden, Sigrid C. Fra-Bido, Silvia Innocentin, Marisa Stebegg, Hanneke Okkenhaug, Nicola Evans-Bailey, Wim Pierson, Alice E. Denton, Michelle A. Linterman   +8 more
doaj   +1 more source

Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia

Journal of Infectious Diseases, 2020
Background In December 2019, novel coronavirus (SARS-CoV-2) pneumonia (COVID-19) was reported in Wuhan and has since rapidly spread throughout China.
Fan Wang, Jia-yan Nie, Haizhou Wang, Qiu Zhao, Yong Xiong, Liping Deng, Shi-hui Song, Zhiyong Ma, Pingzheng Mo, Yongxi Zhang   +9 more
semanticscholar   +1 more source