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Frontiers in Immunology, 2023 IntroductionMHC class II molecules are essential for appropriate immune responses against pathogens but are also implicated in pathological responses in autoimmune diseases and transplant rejection.
Camilla Wibrand +12 more
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The Oncologist, 1999 Abstract Mechanisms in Hematology is a book with an accompanying interactive CD-ROM designed to assemble basic concepts that underlie clinical understanding and progress. It is presented as a concise text with a series of diagrams that distill diffuse information into a compact form.
Esther D. Israels, Lyonel G. Israels and
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Generation of High Quality Memory B Cells
Frontiers in Immunology, 2022 Protection against pathogen re-infection is mediated, in large part, by two humoral cellular compartments, namely, long-lived plasma cells and memory B cells.
Takeshi Inoue +4 more
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Antigen presentation by B cells enables epitope spreading across an MHC barrier
Nature Communications, 2023 Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE)
Cecilia Fahlquist-Hagert +22 more
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Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder [PDF]
Brain Sciences, 2021 Background: Several inflammatory hypotheses have been suggested to explain the etiopathogenesis of bipolar disorder (BD) and its different phases. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and monocyte-to-lymphocyte (MLR) ratios have been proposed as potential peripheral biomarkers of mood episodes.
Antimo Natale +9 more
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Lymphocytes in atherosclerosis [PDF]
Clinica Chimica Acta, 2012 It is well established that atherosclerosis is caused by an inflammatory process in the arterial intima. However, it is only in recent years that it has become clear that this inflammation is modulated by immune responses against plaque antigens. These antigens are primarily believed to be modified self-antigens such as oxidized LDL.
Wigren, Maria +2 more
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Cell Reports, 2017 Adenomatous polyposis coli (APC) is a polarity regulator and tumor suppressor associated with familial adenomatous polyposis and colorectal cancer development.
Sonia Agüera-González +9 more
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Dynamic 3D Locus Organization and Its Drivers Underpin Immunoglobulin Recombination
Frontiers in Immunology, 2021 A functional adaptive immune system must generate enormously diverse antigen receptor (AgR) repertoires from a limited number of AgR genes, using a common mechanism, V(D)J recombination.
Carolyn H. Rogers +2 more
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Heterochronic faecal transplantation boosts gut germinal centres in aged mice
Nature Communications, 2019 Microbiota impacts all major aspects of physiology, but little is known about its effects on age-related changes in immune responses. Here the authors show that gut microbiota transfer between adult and old mice increases local but not systemic germinal ...
Marisa Stebegg +6 more
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Nature Communications, 2021 The Mediator complex regulates RNA polymerase II transcription in all eukaryotes. The mammalian Mediator cryo-EM structure reveals the architecture of previously unresolved Tail module and suggests its regulatory role in the complex conformation and ...
Haiyan Zhao +6 more
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