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IntroductionMHC class II molecules are essential for appropriate immune responses against pathogens but are also implicated in pathological responses in autoimmune diseases and transplant rejection.
Camilla Wibrand+12 more
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Early Interferon-γ Production in Human Lymphocyte Subsets in Response to Nontyphoidal Salmonella Demonstrates Inherent Capacity in Innate Cells [PDF]
Background Nontyphoidal Salmonellae frequently cause life-threatening bacteremia in sub-Saharan Africa. Young children and HIV-infected adults are particularly susceptible.
Anna E. Seeley+5 more
core +14 more sources
Abstract Mechanisms in Hematology is a book with an accompanying interactive CD-ROM designed to assemble basic concepts that underlie clinical understanding and progress. It is presented as a concise text with a series of diagrams that distill diffuse information into a compact form.
Esther D. Israels, Lyonel G. Israels and
openaire +3 more sources
Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder [PDF]
Background: Several inflammatory hypotheses have been suggested to explain the etiopathogenesis of bipolar disorder (BD) and its different phases. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and monocyte-to-lymphocyte (MLR) ratios have been proposed as potential peripheral biomarkers of mood episodes.
Antimo Natale+9 more
openaire +5 more sources
Generation of High Quality Memory B Cells
Protection against pathogen re-infection is mediated, in large part, by two humoral cellular compartments, namely, long-lived plasma cells and memory B cells.
Takeshi Inoue+4 more
doaj +1 more source
Antigen presentation by B cells enables epitope spreading across an MHC barrier
Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE)
Cecilia Fahlquist-Hagert+22 more
doaj +1 more source
Lymphocytes in atherosclerosis [PDF]
It is well established that atherosclerosis is caused by an inflammatory process in the arterial intima. However, it is only in recent years that it has become clear that this inflammation is modulated by immune responses against plaque antigens. These antigens are primarily believed to be modified self-antigens such as oxidized LDL.
Wigren, Maria+2 more
openaire +5 more sources
Antigen-specific electrophoretic cell separation for immunological investigations [PDF]
Preincubation of human blood lymphocytes with cell surface antigen specific antibodies under non-capping conditions reduces the electrophoretic mobility of the corresponding lymphocyte subpopulation.
Hannig, K.+2 more
core +1 more source
Adenomatous polyposis coli (APC) is a polarity regulator and tumor suppressor associated with familial adenomatous polyposis and colorectal cancer development.
Sonia Agüera-González+9 more
doaj +1 more source
Dynamic 3D Locus Organization and Its Drivers Underpin Immunoglobulin Recombination
A functional adaptive immune system must generate enormously diverse antigen receptor (AgR) repertoires from a limited number of AgR genes, using a common mechanism, V(D)J recombination.
Carolyn H. Rogers+2 more
doaj +1 more source