Results 71 to 80 of about 99,740,226 (294)

Comparison of radiological scoring systems, clinical scores, neutrophil-lymphocyte ratio and serum C-reactive protein level for severity and mortality in acute pancreatitis

, 2020
Comparison of radiological scoring systems, clinical scores, neutrophil-lymphocyte ratio and serum C-reactive protein level for severity and mortality in acute ...
GEZER, NACİYE SİNEM, Erkmen, Pakize E., ALTAY, CANAN, Baran, Agah, BENGİ, GÖKSEL, DİCLE, OĞUZ, TOPALAK, ÖMER SELAHATTİN   +6 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Associations of C-reactive protein to lymphocyte ratio and metabolic-dysfunction-associated steatotic liver disease: evidence from NHANES 2017–2018

BMC Gastroenterology
Background This study aimed to investigate the association between Metabolic-dysfunction-associated steatotic liver disease(MASLD)and C-reactive protein/lymphocyte ratio (CLR).
Bowen Liu, Xiaomei Sun, Xiaobin Li, Fenping Lu, Guangyan Xing, Guiping Ma, Yun Ran, Shi Ping Hu   +7 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Prognostic significance of systemic inflammatory markers in esophageal cancer: Systematic review and meta‐analysis

Annals of Gastroenterological Surgery, 2020
Aim Impact of several immune‐inflammatory markers on long‐term outcome has been reported in various malignancies. The aim of the present study was to evaluate through a meta‐analysis the oncological outcome of immune‐inflammatory markers, such as ...
Yusuke Ishibashi, Hironori Tsujimoto, Yoshihisa Yaguchi, Yoji Kishi, Hideki Ueno   +4 more
doaj   +1 more source

Association between Platelet-to-Lymphocyte Ratio, C-reactive Protein to Albumin Ratio, Red Cell Distribution Width, and APACHE II Score in Predicting Prognosis and Mortality in Sepsis [PDF]

Aim: Intensive care unit (ICU) provide critical care and treatment to enhance patient outcomes. There is limited data on new scoring systems that predict prognosis during sepsis.
Yeşim Şerife Bayraktar, Yasemin Cebeci
core   +1 more source

Complicated Acute Cholecystitis: The Role of C-Reactive Protein and Neutrophil-Lymphocyte Ratio as Predictive Markers of Severity.

, 2021
Objectives The clinical diagnosis of complicated acute cholecystitis (CAC) remains difficult with several pathological or ultrasonography criteria used to differentiate it from uncomplicated acute cholecystitis (UAC).
Thakkar, Mehual, Mahmood, Fahad, Jambulingam, Periyathambi, Akingboye, Akinfemi, Malam, Yogeshkumar   +4 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Correlation of inflammatory indices with staging of esophageal carcinoma: a prospective study at Dr. Ruth K M Pfau Civil Hospital, Karachi

Journal of the Pakistan Medical Association
Objective: To determine the correlation between inflammatory indices and the Tumour-Node-Metastasis stage of oesophageal carcinoma. Method: The prospective study was conducted from January 2021 to January 2023 at the Department of Upper ...
Sajida Qureshi, Sumayah Khan, Kashif Shafique, Saba Mughal   +3 more
doaj   +1 more source