Results 81 to 90 of about 99,740,226 (294)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Correlations of neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with biomarkers of atherosclerosis risk and inflammatory response in patients with a history of breast cancer

Pteridines, 2015
The aim of the present study was to evaluate the correlations of peripheral blood cell count (PBC)-derived ratios with neopterin concentration and biomarkers of atherosclerosis risk in patients with history of breast cancer.
Študentová Hana, Vitásková Denisa, Šrámek Vlastislav, Indráková Jarmila, Adam Tomáš, Juráňová Jarmila, Petrová Pavla, Krčmová Lenka Kujovská, Pešková Eliška, Solichová Dagmar, Kalábová Hana, Melichar Bohuslav   +11 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Effects of Prognostic Nutrition Index, Neutrophil/Lymphocyte Ratio, and C-reactive Protein/Albumin Ratio on Prognosis Undergoing Open Heart Surgery [PDF]

Aim: Deficiencies in preoperative nutritional status increase the incidence of negative postoperative events. In this study, we aimed to investigate the effect of the prognostic nutrition index (PNI), neutrophil-to-lymphocyte (N/L) ratio, and C-reactive ...
Ilker Coskun, Ebru Canakci, Merve Elif Demirhan, Nilay Tas, Anil Kilinc, Melih Urkmez   +5 more
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Baseline laboratory characteristics of the study population according to neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).

, 2015
Data is presented as mean ± SD or number (percentage)NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, hs-CRP high sensitivity C-reactive protein, eGFR estimated glomerular filtration rate according to the Modification of Diet in ...
Ae-Young Her (775370), Soe Hee Ann (775368), Kyoung Im Cho (775367), Gillian Balbir Singh (775369), Eun-Seok Shin (775371)   +4 more
core   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Lymphocyte-to-C-reactive protein ratio as a new biomarker for predicting mortality and morbidity in FournierÓ?s gangrene

Cirugía y Cirujanos (English Edition)
The purpose of this study was to research the neutrophil-lymphocyte ratio (NLR), lymphocyte-to-C-reactive protein ratio (LCR), and Fournier's Gangrene Severity Index (FGSI) for predicting prognosis and mortality in patients with Fournier's gangrene (FG).Patients diagnosed with FG and treated in a tertiary referral hospital in the period from January ...
Angin, YAVUZ SELİM, Koca, Bulent, Ozkan, Namik, Ozsoy, Ugur, Saglam, Ali I., Gul, Sinan C., Yildirim, Murat   +6 more
openaire   +3 more sources

Relationship between ZFHX3 SNP rs2106261 genotype and the inflammation markers neutrophil/lymphocyte (N/L) ratio, C-reactive protein (CRP) and interleukin-6 (IL-6).

, 2018
Relationship between ZFHX3 SNP rs2106261 genotype and the inflammation markers neutrophil/lymphocyte (N/L) ratio, C-reactive protein (CRP) and interleukin-6 (IL-6).
Chikaaki Motoda (401856), Kazuaki Chayama (128675), Hidenori Ochi (128649), Takehito Tokuyama (401850), Hiroya Matsumura (4641715), Hiroshi Kawazoe (4543114), Michitaka Amioka (4641721), Shunsuke Tomomori (4641724), Akinori Sairaku (401855), Yasuki Kihara (401869), Naoya Hironobe (610380), Yuko Onohara (4641727), Shou Okamura (5714858), Yukiko Nakano (401847), Yousaku Ookubo (5714855)   +14 more
core   +1 more source