Results 101 to 110 of about 1,723,798 (355)

Genistein induces a protective immunomodulatory effect in a mouse model of cervical cancer [PDF]

, 2012
Background: Genistein (GEN), a naturally occurring flavonoid present in soy bean, has attracted scientific interest for its possible benefits in cancer. Objective: The potential immunomodulatory effects of genistein on the immune system and against TC-1 ...
Alizadeh, A., Ghaemi, A., Gorji, A., Moradi, A., Razeghi, S., Soleimanjahi, H., Tabaraei, A., Vakili, M.A.   +7 more
core   +1 more source

Nodular lymphocyte predominant Hodgkin lymphoma behaves as a distinct clinical entity with good outcome: evidence from 14-year followup in the West of Scotland Cancer Network [PDF]

, 2011
Clinically and biologically, nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) has much more in common with germinal-center derived B-cell non-Hodgkin lymphoma (NHL) than with classical Hodgkin lymphoma (cHL).
Diehl V, Fanale MA, Hasenclever D, Katrina Farrell, Mike Leach, Orlandi E, Pamela Mckay, Savage KJ, Stein H   +8 more
core   +1 more source

Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells

Nature Communications, 2017
Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent ...
Manuel D. Díaz-Muñoz, Vladimir Yu. Kiselev, Nicolas Le Novère, Tomaz Curk, Jernej Ule, Martin Turner   +5 more
doaj   +1 more source

Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes

Frontiers in Immunology, 2018
T lymphocytes, from their first encounter with their specific antigen as naïve cell until the last stages of their differentiation, in a replicative state of senescence, go through a series of phases.
M. Moro-García, J. Mayo, R. Sainz, R. Alonso-Arias   +3 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Air Pollution and Lymphocyte Phenotype Proportions in Cord Blood [PDF]

, 2005
Effects of air pollution on morbidity and mortality may be mediated by alterations in immune competence. In this study we examined short-term associations of air pollution exposures with lymphocyte immunophenotypes in cord blood among 1,397 deliveries in
Caroline E.W. Herr, DiFranza JR, D’Arena G, Garcia LA, Harris D, Irva Hertz-Picciotto, Jesse P. Joad, Kent E. Pinkerton, Michael Lipsett, Miroslav Dostál, Paul Ashwood, Perera F, Poh-Sin Yap, Radim J. Šrám, Robert H. Shumway, Santagostino A   +15 more
core   +2 more sources

Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells

Stem Cell Reports, 2015
Self-renewal potential and multipotency are hallmarks of a stem cell. It is generally accepted that acquisition of such stemness requires rejuvenation of somatic cells through reprogramming of their genetic and epigenetic status.
Tomokatsu Ikawa, Kyoko Masuda, Mirelle J.A.J. Huijskens, Rumi Satoh, Kiyokazu Kakugawa, Yasutoshi Agata, Tomohiro Miyai, Wilfred T.V. Germeraad, Yoshimoto Katsura, Hiroshi Kawamoto   +9 more
doaj   +1 more source

Neutrophil/Lymphocyte Ratio as Predictor of Anastomotic Leak after Gastric Cancer Surgery [PDF]

, 2020
D Rădulescu, Vlad Dumitru Băleanu, Vlad Pădureanu, Patricia Mihaela Rădulescu, Silviu Bordu, Ștefan Pătrașcu, Bogdan Socea, Nicolae Bacalbașa, Valeriu Şurlin, I Georgescu, E Georgescu   +10 more
openalex   +1 more source

The neutrophil-to-lymphocyte ratio: a narrative review

ecancermedicalscience, 2016
Cellular-mediated inflammatory response, lymphocytes, neutrophils, and monocytes are increasingly being recognised as having an important role in tumorigenesis and carcinogenesis.
S. Faria, P. C. Fernandes, M. Silva, V. Lima, W. Fontes, R. Freitas-Junior, A. K. Eterovic, P. Forget   +7 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source