Results 201 to 210 of about 583,949 (268)

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

Nutritional risk and cancer pain as determinants of radiotherapy-induced severe lymphocytopenia: development and validation of a nutrition-integrated predictive nomogram. [PDF]

Front Nutr
Gao M, Dong T, Yuan M, Zhang H, Zhang X, Chen Q, Liu C.   +6 more
europepmc   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Prognostic Value of the C-Reactive Protein × Platelet-to-Lymphocyte Ratio for 28-Day Mortality in Patients With Sepsis: A Retrospective Cohort Study. [PDF]

Health Sci Rep
Duan Y, Zhang Y, Xiao J, Yang M, Wen Y, Huang D.   +5 more
europepmc   +1 more source

Peripheral blood inflammatory indices and their association with hospitalization status in acute exacerbation of chronic obstructive pulmonary disease: A retrospective observational study. [PDF]

J Int Med Res
Ucar Y, Yonar A, Karabulut KU.
europepmc   +1 more source

Association between 12 composite inflammatory indices and postoperative complications in colorectal cancer surgery: a two-center retrospective study. [PDF]

Front Oncol
Pan C, Yu J, Huang S, Wang S, Ni X, Wang H, Zhang C, Xiao F.   +7 more
europepmc   +1 more source

A clinical study of the CALLY index and HALP score for evaluating response to FOLFOX in colorectal cancer with lung metastases. [PDF]

Am J Transl Res
Wang L, Yan X, Luan J, Yang X, Wang C, Li T, Wen H.   +6 more
europepmc   +1 more source