Results 81 to 90 of about 958,254 (366)
Molecular Oncology, EarlyView.This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang +10 more
wiley +1 more source
Biomedical Journal, 2022 T lymphocytes are central cells of adaptive immunity. Activation of T lymphocytes by the antigen receptor of T cells (TCR) and co-stimulatory molecules involve specific signaling components and cascades.
Sylvain Latour
doaj
The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia [PDF]
, 1988 We describe the effect of splenic irradiation (SI) (0,5–1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL).
Aabo +24 more
core +3 more sources
A Nonconventional Analysis of CD$4^{+}$ and CD$8^{+}$ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection [PDF]
arXiv, 2017 A mathematical model from a previous work was re-fitted and analyzed for experimental data regarding the cellular immune response to the lymphocytic choriomeningitis virus. Specifically, the $CD8^{+}$ T cell response to six MHC class I-restricted epitopes (GP* and NP*) and $CD4^{+}$ T cell responses to two MHC class II-restricted epitopes\cite ...
arxiv
The role of T-helper/T-suppressor ratio in the adaptive immune response: a dynamical model [PDF]
, 2017 Recent experimental studies have suggested the ratio between T-helper and T-suppressor lymphocytes as an index of immunosuppression in HIV, cancer, immunosenescence and inflammatory and auto-immune diseases. However, a quantitative understanding of the impact of this ratio on the immune response has lagged behind data and its validity as a tool for ...
arxiv +1 more source
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source
Nature Communications, 2021 A feature of cohesin mutations in patients with Cornelia de Lange Syndrome (CdLS) is intellectual disability, but the underlying mechanisms have remained obscure.
Felix D. Weiss +11 more
doaj +1 more source
Regulated progression of B lymphocyte differentiation from cultured fetal liver. [PDF]
, 1987 Lymphoid fetal liver cultures (LFLC) are long-term, nontransformed cultures of early B lymphoid lineage cells which appear developmentally blocked at the pre-B stage in vitro.
Denis, KA, Dorshkind, K, Witte, ON
core
Stochastic model for computer simulation of the number of cancer cells and lymphocytes in homogeneous sections of cancer tumors [PDF]
arXiv, 2014 We deal with a small enough tumor section to consider it homogeneous, such that populations of lymphocytes and cancer cells are independent of spatial coordinates. A stochastic model based in one step processes is developed to take into account natural birth and death rates.
arxiv
A Weakly Supervised Segmentation Network Embedding Cross-scale Attention Guidance and Noise-sensitive Constraint for Detecting Tertiary Lymphoid Structures of Pancreatic Tumors [PDF]
arXiv, 2023 The presence of tertiary lymphoid structures (TLSs) on pancreatic pathological images is an important prognostic indicator of pancreatic tumors. Therefore, TLSs detection on pancreatic pathological images plays a crucial role in diagnosis and treatment for patients with pancreatic tumors.
arxiv