Results 81 to 90 of about 1,229,989 (271)
B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke
Journal of Neuroscience, 2015 Each year, 10 million people worldwide survive the neurologic injury associated with a stroke. Importantly, stroke survivors have more than twice the risk of subsequently developing dementia compared with people who have never had a stroke.
K. Doyle +12 more
semanticscholar +1 more source
Cell Reports, 2021 Summary: T lymphocyte differentiation in the steady state is characterized by high cellular turnover whereby thymocytes do not self-renew. However, if deprived of competent progenitors, the thymus can temporarily maintain thymopoiesis autonomously.
Rafael A. Paiva +6 more
doaj
A Dynamical Systems Perspective on Chimeric Antigen Receptor T-Cell Dosing [PDF]
, 2018 Chimeric antigen receptor T cells (CAR T cells) are dosed similarly to donor lymphocyte infusions following hematopoietic cell transplantation. In this perspective paper a mathematical basis for personalized dosing of CAR T cells is introduced.
arxiv +1 more source
Cell Reports, 2017 Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in the generation of protective and non-protective subsets of Mtb ...
Michelle A. Sallin +5 more
doaj +1 more source
Cancer Detection via Determination of Fractal Cell Dimension [PDF]
arXiv, 1995 We utilize the fractal dimension of the perimeter surface of cell sections as a new observable to characterize cells of different types. We propose that it is possible to distinguish cancerous from healthy cells with the aid of this new approach. As a first application we show that it is possible to perform this distinction between patients with hairy ...
arxiv
Some thoughts on the ontogenesis in B-cell immune networks [PDF]
arXiv, 2010 We are interested in modeling theoretical immunology within a statistical mechanics flavor: focusing on the antigen-independent maturation process of B-cells, in this paper we try to revise the problem of self vs non-self discrimination by mature B lymphocytes.
arxiv
Nature Communications, 2016 T follicular regulatory cells control the magnitude of the germinal centre response. Here the authors show that these cells display specificity to self as well as foreign antigens, and can arise from Foxp3-negative precursors at early stages of ...
Meryem Aloulou +6 more
doaj +1 more source
Controlling IL-7 injections in HIV-infected patients [PDF]
arXiv, 2018 Immune interventions consisting in repeated injection are broadly used as they are thought to improve the quantity and the quality of the immune response. However, they also raised several questions that remains unanswered, in particular the number of injections to make or the delay to respect between different injections to acheive this goal ...
arxiv
Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice
Nature CommunicationsDe novo synthesis of the pyrimidine, cytidine triphosphate (CTP), is crucial for DNA/RNA metabolism and depends on the CTP synthetases, CTPS1 and −2. Partial CTPS1 deficiency in humans has previously been shown to lead to immunodeficiency, with impaired ...
Claire Soudais +17 more
doaj +1 more source
A mathematical model for chemoimmunotherapy of chronic lymphocytic leukemia [PDF]
arXiv, 2018 Immunotherapy is currently regarded as the most promising treatment to fight against cancer. This is particularly true in the treatment of chronic lymphocytic leukemia, an indolent neoplastic disease of B-lymphocytes which eventually causes the immune system's failure.
arxiv