Results 261 to 270 of about 2,075,479 (379)

Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca2+ Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium

Advanced Science, EarlyView.
The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu, Yong‐jian Guo, Yu‐qi Zhu, Hong‐zheng Wang, Hai‐di Wang, Hong‐yu Chen, Yue‐xin Jiang, Hui Li, Hui Hui   +8 more
wiley   +1 more source

Absolute lymphocyte count predicts efficacy of palbociclib in patients with metastatic luminal breast cancer. [PDF]

BMC Cancer
Kobayashi T, Nishimura M, Hosonaga M, Kizawa R, Kawai S, Aoyama Y, Ozaki Y, Fukada I, Hara F, Takano T, Ueno T.   +10 more
europepmc   +1 more source

Is a raised intraepithelial lymphocyte count with normal villous architecture in duodenal biopsies clinically significant?

, 2001
Sanjiv Mahadeva, Judith I. Wyatt, P D Howdle   +2 more
openalex   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Effect of Hemoglobin, Albumin, Lymphocyte Count, and Platelet (HALP) Score on Survival of Patients with Metastatic Thyroid Cancer Treated with Tyrosine Kinase Inhibitors. [PDF]

J Clin Med
Öztop H, Hunutlu FÇ, Ekizoğlu Sİ, Gül ÖÖ, Cander S, Şahin AB.   +5 more
europepmc   +1 more source

Monoclonal B lymphocytes with the characteristics of “indolent” chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts

, 2002
Andy C. Rawstron, Michael J. Green, Anita Kuzmicki, Ben Kennedy, James A. L. Fenton, Paul Evans, Sheila J.M. O’Connor, Stephen J. Richards, Gareth J. Morgan, Andrew Jack, Peter Hillmen   +10 more
openalex   +1 more source

CD4 Lymphocyte Percentage Predicts Disease Progression in HIV‐Infected Patients Initiating Highly Active Antiretroviral Therapy with CD4 Lymphocyte Counts >350 Lymphocytes/mm³ [PDF]

, 2005
Todd Hulgan, Stephen Raffanti, Asghar Kheshti, Robert B. Blackwell, Peter F. Rebeiro, Gema Barkanic, Brandon Ritz, Timothy R. Sterling   +7 more
openalex   +1 more source

POLE Deficiency Exacerbates Diesel Engine Exhaust‐Induced Genomic Instability and Malignant Transformation of Bronchial Epithelial Cells

Advanced Science, EarlyView.
This study establishes a diesel engine exhaust (DEE)‐induced malignant transformation model in bronchial epithelial cells. Whole genome sequencing（WGS） and RNA‐seq reveal DEE‐induced mutational signatures and gene expression profiles. Mechanistically, DEEaffect polymerase epsilon (POLE) and mismatch repair, driving genomic instability and promoting ...
Pimei Zhang, Zhaoxu Wu, Qiang Ju, Nuo Xu, Xian Chen, Hongguang Chen, Shuaishuai Yang, Jing Ji, Yanjie Zhao   +8 more
wiley   +1 more source

Effect of peripheral blood lymphocyte count on the efficacy of immunotherapy combined with TKI in the treatment of advanced liver cancer. [PDF]

Front Immunol
Zhao Q, Wang L, Fu H, Zhang Y, Xie Q.
europepmc   +1 more source

Assessment of the efficacy of total lymphocyte counts as predictors of AIDS defining infections in HIV-1 infected people [PDF]

, 2005
Justin Stebbing, Shailendra Sawleshwarkar, Christos Michailidis, Rachael Jones, Mark Bower, Sundhiya Mandalia, Mark Nelson, B Gazzard   +7 more
openalex   +1 more source