Results 61 to 70 of about 333,907 (356)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Investigation of Laboratory Parameters That Differentiate Complicated Appendicitis from Simple Appendicitis in Adults

İstanbul Medical Journal, 2019
Introduction:Acute appendicitis is one of the most common abdominal emergencies. In this study, we aimed to investigate preoperative laboratory parameters in patients with simple and complicated appendicitis.Methods:The medical records of patients over ...
Özgür Dikme, Özlem Dikme
doaj   +1 more source

Age-related changes in blood lymphocyte subsets of south Indian children [PDF]

, 2003
Background. Enumeration of lymphocyte subsets has been widely used for the diagnosis and monitoring of several haematological and immunological disorders.
Arunkumar, N, Hanna, L E, Raja, Alamelu, Sankaran, K, Swaminathan, Soumya   +4 more
core  

A multicenter experience using adipose-derived mesenchymal stem cell therapy for cats with chronic, non-responsive gingivostomatitis. [PDF]

, 2020
BackgroundThe ability of mesenchymal stem cells (MSCs) to modulate immune responses inspired a series of clinical trials addressing oral mucosal inflammation.
Arzi, Boaz, Battig, Jean, Borjesson, Dori L, Clark, Kaitlin C, Delatorre, Ubaldo, Fiani, Nadine, Fulton, Amy, Lommer, Milinda J, Loscar, Megan R, Peralta, Santiago, Taechangam, Nopmanee, Vapniarsky, Natalia, Walker, Naomi J   +12 more
core   +1 more source

Mycobacterium tuberculosis Drives Expansion of Low-Density Neutrophils Equipped With Regulatory Activities [PDF]

, 2019
In human tuberculosis (TB) neutrophils represent the most commonly infected phagocyte but their role in protection and pathology is highly contradictory.
La Manna, M. P., Orlando, V., Paraboschi, E. M., Tamburini, B., Di Carlo, P., Cascio, A., Asselta, R., Dieli, F., Caccamo, N.   +8 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Lymphocyte levels in Crohn’s disease patients in clinical remission are significantly lower than those in healthy people

European Journal of Medical Research
Background and purpose Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory bowel disease caused by multiple causes. Lymphocytes migration is involved in the pathogenesis of IBD. The purpose of this study was to evaluate whether there
Asi He, Tulan Hu, Linzhen Li
doaj   +1 more source

Evaluation of inflammatory and hematological parameters in patients diagnosed with COVID-19

Journal of Infection in Developing Countries, 2022
Introduction: This study aims to research the effects of hematological and inflammatory parameters on the prognosis of COVID-19 disease and hospitalization duration.
Çiğdem Mermutluoğlu, Recep Dursun, Fesih Aktar, Saim Dayan, Mustafa Kemal Çelen, Ali Kemal Kadiroğlu, Erdal İnci, Rengin Karagöz, Mahir Kuyumcu, Nida Özcan, Recep Tekin   +10 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

National Institute of Health Stroke Scale Score Mediated the Relationship between Systemic Inflammatory Response Index, High-Sensitivity C-Reactive Protein, and Functional Prognosis of Acute Ischemic Stroke: A Prospective Cross-Sectional Study

Heart and Mind
Background: The systemic inflammatory indicators were reported to relate to the functional prognosis of acute ischemic stroke (AIS). Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII ...
Xueqing Liu, Tong Zhang, Liqin Yang, Guojuan Chen, Peng Ding, Delin Yu, Haibing Liao, Jing Liu, Wei Yue   +8 more
doaj   +1 more source