Results 71 to 80 of about 213,374 (313)

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Dynamic surveillance of lymphocyte subsets in patients with non-small cell lung cancer during chemotherapy or combination immunotherapy for early prediction of efficacy

Frontiers in Immunology
BackgroundNon-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. Lymphocytes are the primary executors of the immune system and play essential roles in tumorigenesis and development.
Shanshan Zhen, Shanshan Zhen, Wenqian Wang, Wenqian Wang, Guohui Qin, Taiying Lu, Li Yang, Li Yang, Li Yang, Yi Zhang, Yi Zhang, Yi Zhang   +11 more
doaj   +1 more source

Mycobacterium tuberculosis Drives Expansion of Low-Density Neutrophils Equipped With Regulatory Activities [PDF]

, 2019
In human tuberculosis (TB) neutrophils represent the most commonly infected phagocyte but their role in protection and pathology is highly contradictory.
La Manna, M. P., Orlando, V., Paraboschi, E. M., Tamburini, B., Di Carlo, P., Cascio, A., Asselta, R., Dieli, F., Caccamo, N.   +8 more
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

A diagnostic prediction model was established based on the clinical characteristics of multicenter children with Kawasaki disease in Xinjiang

Frontiers in Cardiovascular Medicine
IntroductionKawasaki disease (KD) is a serious pediatric systemic vasculitis that may cause cardiovascular complications, including coronary artery lesions (CAL).
Muqing Niu, Zhaotang Lin, Fengling Zhang, Yonglin Chen, Li Zhang, Jinyong Pan, Cailing Chen, Hongbin Yang, Lian Mao, Lijuan Chen, Hua Guan, Yong Sun, Zhou Zhang, Jing Lv   +13 more
doaj   +1 more source

Enrichment of innate lymphoid cell populations in gingival tissue [PDF]

, 2018
Innate lymphoid cells (ILCs) are a population of lymphocytes that act as the first line of immunologic defense at mucosal surfaces. The ILC family in the skin, lungs, and gastrointestinal tissues has been investigated, and there are reports of individual
Adrados Planell, A., Brown, J.L., Butcher, J.P., Campbell, L., Culshaw, S., Malcolm, J.   +5 more
core   +2 more sources

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Changes of Peripheral Blood Lymphocyte Subsets in 212 Active Tuberculosis Patients: A Uni-centered Descriptive Study

Xiehe Yixue Zazhi, 2023
Objective  To explore the characteristics and their significance of peripheral blood lymphocyte subsets in patients with active tuberculosis(ATB), based on a relatively large sample.
XIE Lantian, RUAN Guiren, LIU Xiaoqing, ZHANG Lifan, ZHANG Yueqiu, QIU Zhifeng, SHI Xiaochun   +6 more
doaj   +1 more source

Lymphocytes subsets reference values in childhood [PDF]

Cytometry Part A, 2014
AbstractImmunophenotyping of blood lymphocyte subsets and activation markers is a basic tool in the diagnostic process of primary immunodeficiency diseases, its use becoming more and more widespread as the knowledge about these illnesses increases. However, the availability of reliable reference values, which need to be age‐matched for the pediatric ...
TOSATO, FRANCESCA, Bucciol G, Pantano G, Putti MC, SANZARI, MARIA COLOMBA, BASSO, GIUSEPPE, PLEBANI, MARIO   +6 more
openaire   +3 more sources

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source