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Reporting Tumor Infiltrating Lymphocytes
2012The presence of many tumor infiltrating lymphocytes (TILs) in primary cutaneous melanoma is associated with a better prognosis. The degree of lymphocytic interaction with the tumor cells is graded as “brisk”, “non-brisk” or “absent” as defined below:
Kasia Szyfelbein Masterpol +2 more
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Tumor-infiltrating lymphocytes predict cutaneous melanoma survival
Melanoma Research, 2015Understanding differences in survival across distinct subgroups of melanoma patients may help with the choice of types of therapy. Tumor-infiltrating lymphocytes (TILs) are considered a manifestation of the host immune response to tumor, but the role of TILs in melanoma mortality is controversial.
Cristina, Fortes +9 more
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Tumor-infiltrating lymphocytes: A new hope
Cancer CellTumor-infiltrating lymphocytes (TILs) can be massively expanded from resected tumors and used as a cellular treatment for advanced malignancies. TILs require a preparative non-myeloablative chemotherapy followed by an abbreviated course of interleukin-2.
Amod A, Sarnaik +3 more
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Tumor-Infiltrating Lymphocyte Therapy and Neoantigens
The Cancer Journal, 2017The adoptive cell transfer (ACT) of autologous tumor-infiltrating lymphocytes has been shown to be effective at mediating tumor regression in more than half of patients with metastatic melanoma and in mediating long-term complete regression in approximately one fourth of all patients with this cancer.
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Tumor-infiltrating lymphocytes from nonrenal urological malignancies
Cancer Immunology Immunotherapy, 1990Tumor-infiltrating lymphocytes (TIL) were isolated from 15 of 20 surgical specimens of transitional cell carcinoma of the urinary bladder, prostate cancer, testicular cancer, Wilms tumor and adrenal cancer. Expansion was carried out in four different culture conditions, each containing 1000 U/ml interleukin-2: RPMI medium with or without 20% (by volume)
G P, Haas, D, Solomon, S A, Rosenberg
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TUMOR INFILTRATING LYMPHOCYTES*
Annals of the New York Academy of Sciences, 1976E, Klein +4 more
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Tumor-infiltrating lymphocytes
Critical Reviews in Oncology/Hematology, 1992Theresa L. Whiteside +2 more
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Tumor-Infiltrating Lymphocyte Therapy in Advanced Melanoma
New England Journal of Medicine, 2023Maartje W, Rohaan +2 more
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