Results 301 to 310 of about 317,356 (325)

Tumor-infiltrating lymphocytes and POLE mutation in endometrial carcinoma

Gynecologic Oncology, 2021
Polymerase-ε (POLE)-mutated endometrial carcinomas (ECs) have displayed an increased number of tumor-infiltrating lymphocytes (TIL) compared to POLE-wild-type ECs. However, it is unclear if TIL may aid in identifying POLE-mutated ECs when molecular data are unavailable.
Raffone A., Travaglino A., Raimondo D., Boccellino M. P., Maletta M., Borghese G., Casadio P., Insabato L., Mollo A., Zullo F., Seracchioli R.   +10 more
openaire   +5 more sources

Tumor-Infiltrating Lymphocyte Therapy and Neoantigens

The Cancer Journal, 2017
The adoptive cell transfer (ACT) of autologous tumor-infiltrating lymphocytes has been shown to be effective at mediating tumor regression in more than half of patients with metastatic melanoma and in mediating long-term complete regression in approximately one fourth of all patients with this cancer.
openaire   +3 more sources

Clinical Significance of Tumor-Infiltrating Lymphocytes in Lung Neoplasms [PDF]

The Annals of Thoracic Surgery, 2009
Tumor-infiltrating lymphocytes (TIL) are considered important in anticancer immunosurveillance, although their role has not been clearly established yet. We examined prevalence, correlations, and prognostic significance of TIL among our patient population of resected lung neoplasms.From 1993 to 2006, the presence of TIL was retrospectively evaluated in
RUFFINI, Enrico, ASIOLI, Sofia, FILOSSO, Pier Luigi, Lyberis P, Bruna MC, Macrì L, DANIELE, Lorenzo, OLIARO, Alberto   +7 more
openaire   +3 more sources

Immunotyping and Quantification of Melanoma Tumor–Infiltrating Lymphocytes

2021
The density of tumour-infiltrating lymphocytes (TILs) in melanoma is correlated with improved clinical prognosis; however, standardized TIL immunotyping and quantification protocols are lacking. Herein, we provide a review of the technologies being utilized for the immunotyping and quantification of melanoma TILs.
Zeyad T. Sahli, Max O. Meneveau, Craig L. Slingluff, Ileana S. Mauldin, Kevin T. Lynch   +4 more
openaire   +3 more sources

Tumor-infiltrating lymphocytes: A new hope

Cancer Cell
Tumor-infiltrating lymphocytes (TILs) can be massively expanded from resected tumors and used as a cellular treatment for advanced malignancies. TILs require a preparative non-myeloablative chemotherapy followed by an abbreviated course of interleukin-2.
Amod A, Sarnaik, Patrick, Hwu, James J, Mulé, Shari, Pilon-Thomas   +3 more
openaire   +2 more sources

Predictors of Tumor-Infiltrating Lymphocyte Efficacy in Melanoma

Immunotherapy, 2015
In the past decades, the increasing knowledge in cellular immunology and tumor-host immune interactions, led to the development of immunotherapy approaches. Immunotherapy, based on adoptive cell transfer of ex vivo activated and expanded tumor-infiltrating T lymphocytes (TILs), has shown promising clinical results in patients with metastatic melanoma ...
Michal J. Besser, Michal J. Besser, Jacob Schachter, Dragoslav Zikich   +3 more
openaire   +3 more sources

Variation in the Incidence and Magnitude of Tumor-Infiltrating Lymphocytes in Breast Cancer Subtypes: A Systematic Review.

JAMA Oncology, 2016
Importance The presence of tumor-infiltrating lymphocytes (TILs) is a favorable prognostic factor in breast cancer, and TILs may synergize with chemotherapy and immune checkpoint inhibitor therapy for improved clinical response.
S. Stanton, S. Adams, M. Disis
semanticscholar   +1 more source

Immunopriming of Tumor Infiltrating Lymphocytes with Neoadjuvant Cyclophosphamide

Immunological Investigations, 1993
Tumor infiltrating lymphocytes (TIL) are increasingly employed in immunotherapy protocols. When modified and expanded they can be utilized in new therapeutic protocols. TIL augmentation can be in vitro and in vivo. The purpose of this article is to review the various methods of TIL augmentation and report our experience with a neoadjuvant technique of ...
M. Rubenstein, M. Shaw, P. Guinan
openaire   +3 more sources

Tumor-infiltrating Lymphocytes and Prognosis of Hepatocellular Carcinoma

Japanese Journal of Clinical Oncology, 1992
Tumor-infiltrating lymphocytes (TIL) were isolated from 17 human hepatocellular carcinomas (HCC). The proliferation of TIL cultured with recombinant interleukin-2 (rIL-2) was evaluated. We also examined prognosis in relation to TIL. Successful expansion of TIL was achieved in 16 of the 17 lesions.
Hiroshi Kobayashi, Yoshie Une, Masuo Hosokawa, Akira Kawata, Junichi Uchino   +4 more
openaire   +3 more sources

Targeting tumor microenvironment using tumor-infiltrating lymphocytes as therapeutics against tumorigenesis

Immunologic research, 2023
Hina Qayoom, Shazia Sofi, M. A. Mir
semanticscholar   +1 more source