TIAger: Tumor-Infiltrating Lymphocyte Scoring in Breast Cancer for the TiGER Challenge [PDF]
arXiv, 2022 The quantification of tumor-infiltrating lymphocytes (TILs) has been shown to be an independent predictor for prognosis of breast cancer patients. Typically, pathologists give an estimate of the proportion of the stromal region that contains TILs to obtain a TILs score.
arxiv
Tumor-Infiltrating Lymphocytes—Location for Prognostic Evaluation [PDF]
Clinical Cancer Research, 2019 Abstract Tumor-infiltrating lymphocytes (TIL) are crucial for the success of immunotherapy, and their density can predict prognosis. It has now been shown that computer-based analysis of the spatial organization of TILs adds prognostic value in early-stage non–small cell lung cancer, possibly improving the treatment algorithm to prevent ...
Michael Peled, Roy S. Herbst, Amir Onn
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Association of tumor deposits with tumor-infiltrating lymphocytes and prognosis in gastric cancer
World Journal of Surgical Oncology, 2022 Background To investigate the relationship between tumor deposits (TDs) with the clinicopathological characteristics tumor-infiltrating lymphocytes (TILs) and prognosis of gastric cancer.
Xinyue Li, Jing Yang
doaj +1 more source
Restoring Lost Anti-HER-2 Th1 Immunity in Breast Cancer: A Crucial Role for Th1 Cytokines in Therapy and Prevention [PDF]
, 2016 The ErbB/B2 (HER-2/neu) oncogene family plays a critical role in the development and metastatic spread of several tumor types including breast, ovarian and gastric cancer.
Czerniecki, Brian J. +4 more
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Immunology of Tumor Infiltrating Lymphocytes
Annals of Surgery, 1985 Frequently peripheral blood lymphocytes (PBL) do not reflect the tumor host relationship and cell mediated immunity in the PBL does not often correlate with prognosis. The tumor infiltrating lymphocytes (TIL) interact most closely with the tumor cells and are likely to more accurately reflect tumor host interactions.
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Inhibition of HIF-1 alpha by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma [PDF]
, 2015 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Acland +49 more
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Transcriptomic profiling of tumor-infiltrating CD4 + TIM-3 + T Cells reveals their suppressive, exhausted, and metastatic characteristics in colorectal cancer patients [PDF]
, 2020 T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the tumor microenvironment (TME).
Abu Nada, M +10 more
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Frontiers in Immunology, 2014 There is increasing clinical evidence indicating that the immune system may either promote or inhibit tumor progression. Several studies have demonstrated that tumors undergoing remission are largely infiltrated by T lymphocytes (tumor-infiltrating ...
Elena eLo Presti +2 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2020 Background Adrenocortical carcinoma (ACC) is a rare endocrine malignancy. Tumor-related glucocorticoid excess is present in ~60% of patients and associated with particularly poor prognosis.
Laura-Sophie Landwehr +7 more
semanticscholar +1 more source
Tumor infiltrating lymphocytes and radiological picture of the tumor
Medical Oncology, 2023 AbstractTumor microenvironment (TME) is a complex entity that includes besides the tumor cells also a whole range of immune cells. Among various populations of immune cells infiltrating the tumor, tumor infiltrating lymphocytes (TILs) are a population of lymphocytes characterized by high reactivity against the tumor component.
Karolina Frankowska +3 more
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