Results 221 to 230 of about 23,252 (297)
XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease
MedComm, Volume 7, Issue 5, May 2026.XIAP deficiency leads to impaired colonic tuft cells development and JAK–‐STAT pathway hyperactivation in CD patients and mice. Mechanically, XIAP regulates tuft cells development through Wnt–‐TLE4/TCF–‐ASCL2 signaling. Tuft cells deficiency predisposes XIAP‑‐deficient CD patients or Xiap−/−‐/‐ mice to hazardous microbial effects, driving colonic ...
Rongli Fang +28 more
wiley +1 more source
Heterogeneity in Histological Evaluation of Microscopic Colitis in Randomized Clinical Trials: An Umbrella Review. [PDF]
Inflamm Bowel DisYuan Y +7 more
europepmc +1 more source
Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies
MedComm, Volume 7, Issue 5, May 2026.Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang +8 more
wiley +1 more source
Risk of Safety Events in Vitiligo Patients: A Retrospective Real‐World Data Study in the US
The Journal of Dermatology, Volume 53, Issue 5, Page 758-773, May 2026.ABSTRACT Vitiligo is a chronic autoimmune depigmenting disease characterized by loss of pigment in the skin, hair, or both. As treatment options evolve, particularly with the emergence of oral Janus kinase inhibitors and dual Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor, it is essential to assess ...
Kennedy Cook +11 more
wiley +1 more source
Aging Cell, Volume 25, Issue 5, May 2026.This study explores the impact of aging on regeneration of the mouse colonic epithelium. The authors find that old mice exhibit excessive and prolonged inflammation after infection with Citrobacter, resulting in the maintenance of a fetal regenerative state in epithelial cells, insufficient tissue repair, and death of the animal.
Antonion Korcari +10 more
wiley +1 more source
Aged Gut Microbiota Induces Mucosal Transcriptional Dysregulation, Impairing Immune Surveillance
Aging Cell, Volume 25, Issue 5, May 2026.Aging impaired intestinal mucosal immune homeostasis by altering the epithelial barrier, lamina propria immune cells, follicle‐associated epithelium, and gut microbiota. These changes, particularly the accumulation of pro‐inflammatory bacteria in the gut microbiota, are closely associated with dysregulation of follicle‐associated epithelium gene ...
Fang Wu +10 more
wiley +1 more source
Olive Waste as Feed Supplement: Morphometrical Effects on the Ansa spiralis coli in Lambs
Anatomia, Histologia, Embryologia, Volume 55, Issue 3, May 2026.ABSTRACT Feedlot systems for small ruminants require nutritionally adequate and viable diets, and the incorporation of olive residues can offer a sustainable and economically advantageous alternative. This study evaluated the effects of including olive waste at 7.5%, 15%, 22.5% and 30% in the diets of Texel × Ile‐de‐France lambs, assessing the ...
Gabriel Soares Tosatto Pellenz +8 more
wiley +1 more source