Results 71 to 80 of about 154,837 (273)

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

The frequency of microscopic and focal active colitis in patients with irritable bowel syndrome

BMC Gastroenterology, 2011
Background Irritable bowel syndrome (IBS) is a chronic functional bowel disorder. The frequency of microscopic colitis and focal active colitis in the colonic mucosa has been investigated in IBS patients. Methods Between June 2007 and September 2010, 378
Akyuz Umit, Nigdelioglu Adil, Kahraman Resul, Calhan Turan, Sahin Abdurrahman, Ozdil Kamil, Sokmen Hacı M   +6 more
doaj   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Lymphocytic colitis : a retrospective clinical study of 199 Swedish patients

, 2004
Background: Lymphocytic colitis is characterised by chronic diarrhoea and specific microscopic changes in a macroscopically normal colonic mucosa. We report clinical features and treatment outcome in a large patient cohort.Methods: Patients were searched
Olesen, Martin,, Tysk, Curt,, Eriksson, S.,, Bohr, J.,, Järnerot, Gunnar,   +4 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Microscopic colitis:Current status, present and future challenges: statements of the European Microscopic Colitis Group

, 2012
Microscopic colitis (MC) is an inflammatory bowel disease presenting with chronic, non-bloody watery diarrhoea and few or no endoscopic abnormalities.
Bonderup, Ole Kristian, Ström, M, Hjortswang, H.,, Fernández Bañares, F, Munck, L K, Tysk, C.,, Bonderup, O.,, Bohr, Johan,, Hjortswang, H, Münch, A.,, Madisch, A.,, Bañares, F. Fernández,, Münch, A, Miehlke, S, Aust, D.,, Aust, D, Ström, M.,, Hjortswang, Henrik,, Madisch, A, Miehlke, S.,, Fernandez Banares, F.,, Bohr, J.,, Ström, Magnus,, Munck, L. K.,, Bohr, Jakob, Münch, Andreas,, Tysk, Curt,, Tysk, C   +27 more
core   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

CLINICAL AND PATHOMORPHOLOGICAL CHARACTERISTICS OF PATIENTS WITH MICROSCOPIC COLITIS: A RETROSPECTIVE STUDY

Паёми Сино
Objective: To analyze the clinical and histological data of patients with microscopic colitis (MC). Methods: A retrospective analysis was performed of risk factors and the clinical and morphological features of MC (n=47), including analyses by patient
Savzikhanova Renata Rashidovna, Iskhakova Dilyara Gabdrashidovna, Khazova Elena Vladimirovna, Kazykhanova Yulduz Aidarovna, Danilova Natalya Aleksandrovna, Kulagin Roman Nikolaevich   +5 more
doaj   +1 more source

Immunohistochemical characterization of lymphocytes in microscopic colitis

, 2013
Background and Aims: Microscopic colitis (MC), encompassing the subgroups collagenous colitis (CC) and lymphocytic colitis (LC), is characterized by macroscopically normal or near-normal colonic mucosa, and an increased number of intraepithelial ...
Bohr, Johan,, Göranzon, C.,, Tysk, Curt,, Nyhlin, Nils,, Hultgren-Hörnqvist, Elisabeth,, Eriksson, S.,, Kumawat, Ashok Kumar,   +6 more
core   +1 more source

A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis

Advanced Science, EarlyView.
This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang, Miaoyu Li, Tiantian Li, Xiaojie Zang, Haiyang Shi, Yaru Liu, Chengcheng Zhang, Jianxin Zhao, Qixiao Zhai, Wei Chen, Fengwei Tian   +10 more
wiley   +1 more source