Results 151 to 160 of about 13,338 (182)
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Hemophagocytic Lymphohistiocytosis in the Elderly
The American Journal of the Medical Sciences, 2019Hemophagocytic lymphohistiocytosis (HLH) is a rare disease of massive, dysregulated cytokine release and secondary multiorgan failure and is associated with high mortality. Primary HLH occurs predominately in infants and young children with a genetic predisposition.
Reyna, Altook +7 more
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Lamotrigine and hemophagocytic lymphohistiocytosis
Neurology, 2019Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening syndrome of hyperinflammatory responses with aberrant activation of lymphocytes and macrophages resulting in hypercytokinemia (a positive feedback loop between cytokines and immune cells, with highly elevated levels of various cytokines).1 The syndrome has multiple etiologies including
Kimford J, Meador, Barry E, Gidal
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Familial hemophagocytic lymphohistiocytosis
Diagnostic Cytopathology, 1988AbstractThe cytologic features of familial hemophagocytic lymphohistiocytosis in two infant siblings were reviewed and compared to the histopathologic features in the same cases. The cytologic features of familial hemophagocytic lymphohistiocytosis in imprint smears from the spleen, lymph nodes, and liver were distinct, with proliferation of benign ...
M F, Lachman, E H, Vogel, K, Kim
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Neonatal Hemophagocytic Lymphohistiocytosis
NeoReviews, 2019Hemophagocytic lymphohistiocytosis (HLH) is extremely rare in the neonatal period. The incidence of neonatal HLH is not confirmed and may range from 1 in 50,000 to 150,000. The incidence varies based on ethnicity, particularly in populations in which consanguinity is common.
Josef, McLean +4 more
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Familial hemophagocytic lymphohistiocytosis
European Journal of Pediatrics, 1983Familial hemophagocytic lymphohistiocytosis (FHL) is probably a genetically transmitted disease affecting infants and very young children. Cardinal symptoms are fever, hepatosplenomegaly, and pancytopenia. Frequently meningeal involvement is seen, manifested by neurologic symptoms and a lymphohistiocytic pleocytosis with increased protein levels in the
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Familial hemophagocytic lymphohistiocytosis. Primary hemophagocytic lymphohistiocytosis.
Hematology/oncology clinics of North America, 1998Hemophagocytic lymphohistiocytosis represents a spectrum of pathogenetically different diseases including the rapidly fatal autosomal recessive disease of familial hemophagocytic lymphohistiocytosis (FHL). The onset is usually during the first years of life with fever, cytopenia, and hepatosplenomegaly. Neurologic symptoms may supervene.
J I, Henter +4 more
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History of Hemophagocytic Lymphohistiocytosis
2019Hemophagocytic lymphohistiocytosis (HLH) is a severe cytokine storm syndrome (CSS), which until the turn of the century, was barely known but is now receiving increased attention. The history of HLH dates back to 1939 when it was first described in adults, to be followed in 1952 by the first description of its primary, familial form in children ...
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Familial Hemophagocytic Lymphohistiocytosis
Hematology/Oncology Clinics of North America, 2015Familial hemophagocytic lymphohistiocytosis (FHL) is a rare heritable disorder of immune regulation that is typically characterized by sudden onset of severe systemic illness. Functional impairment or absence of 1 or more of several proteins that participate in lymphocyte cytotoxicity underlies the disease. Although FHL usually presents in infancy, age
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Hemophagocytic Lymphohistiocytosis and Other Hemophagocytic Disorders
Immunology and Allergy Clinics of North America, 2008Hemophagocytic disorders result when critical regulatory pathways responsible for the natural termination of immune/inflammatory responses are disrupted or overwhelmed. Hemophagocytic disorders reflect pathologic defects that alter the normal crosstalk between innate and adaptive immune responses, and compromise homeostatic removal of cells that are ...
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Hemophagocytic lymphohistiocytosis in adults
BloodAbstract Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hematologic disorder characterized by unchecked immune activation and hyperinflammation, resulting in end-organ tissue damage and high mortality rates in untreated patients.
Joanne I. Hsu +2 more
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